ANTITUMOR EFFECTS OF SAIKOSAPONINS, BAICALIN AND BAICALEIN ON HUMAN HEPATOMA-CELL LINES
ANTITUMOR EFFECTS OF SAIKOSAPONINS, BAICALIN AND BAICALEIN ON HUMAN HEPATOMA-CELL LINES
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DOI：
10.1016/0304-3835(94)90184-8
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发表时间：
1994-10-28
期刊：
影响因子：
9.7
通讯作者：
SAWABU, N
中科院分区：
文献类型：
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作者：
MOTOO, Y;SAWABU, N
本研究以人肝癌细胞株（PLC/PRF/5，Hep-G2）、人肝细胞株（Chang）和人胰腺癌细胞株（BxPC-3）为实验对象，研究了中药“小柴胡汤”的9种成分的抗肿瘤作用。抑制PLC/PRF/5细胞生长50%所需的各组分浓度如下：柴胡皂苷-d，黄芩苷，20 μ g/ml;柴胡皂苷-a，黄芩素，50 μ g/ml;柴胡皂苷-b（2），-c，柴胡皂苷-Rb-1，-Rg（1），黄芩素，> 1000 μ g/ml。50 μ g/ml的柴胡皂苷-a抑制所有测试细胞系的细胞生长和DNA合成。这些结果表明，“Sho-saiko-to”包括有效的抗肿瘤成分，如柴胡皂苷-a，-d，黄芩苷和黄芩素对人肝癌细胞以及其他人细胞系。
Antitumor effects of nine components of a herbal medicine, 'Sho-saiko-to', were investigated on human hepatoma cell lines (PLC/PRF/5, Hep-G2), human liver cells (Chang) and a human pancreatic cancer cell line (BxPC-3). The concentration of each component required for 50% inhibition of cell growth of PLC/PRF/5 cells was as follows: saikosaponin-d, baicalin, 20 mu g/ml; saikosaponin-a, baicalein, 50 mu g/ml; saikosaponin-b(2), -c, ginsenoside-Rb-1, -Rg(1), glycyrrhizin, > 1000 mu g/ml. Saikosaponin-a in 50-mu g/ml quantities inhibited the cell growth and DNA synthesis of all the cell lines tested. These results indicate that 'Sho-saiko-to' includes potent antitumor components such as saikosaponin-a, -d, baicalin and baicalein against human hepatoma cells as well as other human cell lines.