The roles and perspectives of microRNAs as biomarkers for intervertebral disc degeneration
The roles and perspectives of microRNAs as biomarkers for intervertebral disc degeneration
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microRNA 作为椎间盘退变生物标志物的作用和前景。
DOI：
10.1002/term.2261
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发表时间：
2017
影响因子：
3.3
通讯作者：
Peng Songlin
中科院分区：
文献类型：
--
作者：
Zhou Xiaoya;Chen Lili;Grad Sibylle;Alini Mauro;Pan Haobo;Yang Dazhi;Zhen Wanxin;Li Zhizhong;Huang Shishu;Peng Songlin
microRNA（miRNAs）是高度保守的分子，在转录后调节蛋白质水平。异常的miRNA表达存在于各种肌肉骨骼疾病中，例如骨质疏松症、骨关节炎和类风湿性关节炎。miRNA的表达水平由内源性和组织特异性表征。这增加了miRNA在某些疾病诊断中作为有用的临床生物标志物的可能性。椎间盘退变（IDD）是背痛的主要原因之一，是一个以分子、细胞、生物化学和结构变化级联为特征的过程。在椎间盘退变疾病患者中存在失调的miRNA表达，表明miRNA可能在IDD的发病机制中起重要作用。本文就miRNAs在IDD发病过程中的作用及作为IDD生物标志物的应用前景作一综述。版权所有© 2017约翰威利父子有限公司
MicroRNAs (miRNAs) are highly conserved molecules that regulate protein levels post‐transcriptionally. Aberrant miRNA expression presents in various musculoskeletal disorders, such as osteoporosis, osteoarthritis and rheumatoid arthritis. The expression levels of miRNAs are characterized by endogenous properties and tissue specificity. This raises the possibility that miRNAs could serve as useful clinical biomarkers in the diagnosis of certain diseases. Intervertebral disc degeneration (IDD) is one of the major causes of back pain, and a process characterized by a cascade of molecular, cellular, biochemical and structural changes. The presence of dysregulated miRNA expression in patients with disc degeneration diseases indicates that miRNAs may play a vital role in the pathogenesis of IDD. Here, we provide an introduction of the roles of miRNAs in the process of IDD, and the prospective application of miRNAs as biomarkers for IDD. Copyright © 2017 John Wiley & Sons, Ltd.