Comment on: Brain Microbleeds and Alzheimer’s Disease: Innocent Observation or Key Player?
Comment on: Brain Microbleeds and Alzheimer’s Disease: Innocent Observation or Key Player?
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DOI：
10.1007/s00062-011-0063-8
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发表时间：
2011-04
影响因子：
2.8
通讯作者：
Horst Urbach
中科院分区：
文献类型：
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作者：
Horst Urbach
脑微出血是小点状病变，在梯度回波 T2 磁共振序列上表现为低信号。在阿尔茨海默病（AD）中，大脑微出血受到特别关注，因为它们可能在病理生理学中发挥着至关重要的作用。它们可能是 AD 神经发病机制的两个重要理论（淀粉样蛋白级联假说和血管假说）之间缺失的一环。此外，它们可能影响疾病的临床病程并可能产生治疗效果。本文的目的是回顾现有数据，以了解脑微出血的临床意义以及 AD 背景下的潜在病理学。还回顾了现有的证据，并强调了临床试验设计中当前关于脑微出血的知识的缺陷。
Brain microbleeds are small dot-like lesions appearing as hyposignals on gradient echo T2 magnetic resonance sequences. In Alzheimer’s disease (AD) brain microbleeds are of special interest as they may play a crucial role in the pathophysiology. They may be a missing link between two important theories on the neuropathogenesis of AD, the amyloid cascade hypothesis and the vascular hypothesis. Moreover, they may affect the clinical course of the disease and may have therapeutic consequences. The aim of this article was to review the available data to understand the meaning of brain microbleeds in clinical terms and the underlying pathology in the context of AD. The available evidence is also reviewed and the pitfalls of the current knowledge on brain microbleeds in the setting of clinical trial design are highlighted.