ORBITOFRONTAL CORTEX REFLECTS CHANGES IN RESPONSE-OUTCOME CONTINGENCIES DURING PROBABILISTIC REVERSAL LEARNING
ORBITOFRONTAL CORTEX REFLECTS CHANGES IN RESPONSE-OUTCOME CONTINGENCIES DURING PROBABILISTIC REVERSAL LEARNING
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DOI：
10.1016/j.neuroscience.2016.03.034
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发表时间：
2017-03-14
期刊：
影响因子：
3.3
通讯作者：
Roitman, J. D.
中科院分区：
文献类型：
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作者：
Amodeo, L. R.;Mcmurray, M. S.;Roitman, J. D.
在不断变化的环境中，行为结果很少是确定的，动物必须能够学会随着时间的推移整合来自其选择的反馈，并适应不断变化的奖励意外事件，以保持灵活的行为。前额皮质（OFC）的眶额区被广泛认为在灵活控制行为的能力中发挥着重要作用。我们使用概率逆转学习任务来测量大鼠的行为灵活性及其在 OFC 中单个神经元活动中的神经基础。在此任务中，一个被指定为“正确”的杠杆以高概率 (80%) 获得奖励，而另一个空间上不同的杠杆被指定为“不正确”，以低概率 (20%) 获得奖励。一旦老鼠达到可靠地选择正确杠杆的学习标准，两个杠杆的奖励意外事件就会互换，并进行每日训练，直到老鼠可靠地选择新的正确杠杆。所有大鼠都成功执行了最初的获取和随后的逆转，需要更多的训练来学习逆转。 OFC 神经元在涵盖习得和逆转学习的五个行为过程中被记录。 OFC 中神经反应的主要模式是通过对记录的神经元群体的主成分分析来确定的，并受到行为过程中奖励结果的调节。一般来说，有奖励的选择后的活动比无奖励的活动要高。然而，错误选择后对奖励的反应减少与对正确杠杆的偏好的建立之间存在相关性。这些结果表明，单个 OFC 神经元的信号传导如何参与不断变化的奖励意外情况下行为的灵活适应。本文是题为“认知灵活性”的特刊的一部分。 (C) 2016 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
In a continuously changing environment, in which behavioral outcomes are rarely certain, animals must be able to learn to integrate feedback from their choices over time and adapt to changing reward contingencies to maintain flexible behavior. The orbitofrontal region of prefrontal cortex (OFC) has been widely implicated as playing a role in the ability to flexibly control behavior. We used a probabilistic reversal learning task to measure rats' behavioral flexibility and its neural basis in the activity of single neurons in OFC. In this task, one lever, designated as 'correct', was rewarded at a high probability (80%) and a second, spatially distinct lever, designated as 'incorrect', was rewarded at a low probability (20%). Once rats reached a learning criterion for reliably selecting the correct lever, reward contingencies of the two levers were switched, and daily sessions were conducted until rats reliably selected the new correct lever. All rats performed the initial Acquisition and subsequent Reversal successfully, with more sessions needed to learn the Reversal. OFC neurons were recorded during five behavioral sessions spanning Acquisition and Reversal learning. The dominant pattern of neural responding in OFC, identified by principal component analysis of the population of neurons recorded, was modulated by reward outcome across behavioral sessions. Generally, activity was higher following rewarded choices than unrewarded. However, there was a correlation between reduced responses to reward following incorrect choices and the establishment of the preference for the correct lever. These results show how signaling by individual OFC neurons may participate in the flexible adaptation of behavior under changing reward contingencies. This article is part of a Special Issue entitled: Cognitive Flexibility. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.