25-Gauge vitrectomy to treat ocular complications of familial amyloid polyneuropathy
25-Gauge vitrectomy to treat ocular complications of familial amyloid polyneuropathy
复制标题
DOI：
10.1097/01.ijg.0000212291.85669.21
复制
发表时间：
2007-01-01
影响因子：
2
通讯作者：
Murata, Toshinori
中科院分区：
文献类型：
--
作者：
Miyahara, Teruyoshi;Ohta, Kouichi;Murata, Toshinori
目的：继发性青光眼和玻璃体混浊伴淀粉样蛋白原纤维是家族性淀粉样蛋白多发性神经病（FAP）的两种主要眼部并发症。我们研究了25号玻璃体切除术在已行小梁切除术的眼内切除不透明玻璃体的可行性。方法：对2眼玻璃体淀粉样变性患者行25号玻璃体切除术，以恢复视力。双眼均行小梁切除术治疗FAR继发青光眼，25号玻璃体切除术后滤过泡存活情况也进行了评估。结果：25号玻璃体切除术后的第二天视力显著改善，对眼睛的损害最小。在6个月的随访期间，没有观察到明显的并发症，包括滤过泡失败。结论：25号玻璃体切除术有可能成为FAP中含有淀粉样原纤维的不透明玻璃体切除的首选治疗方法，特别是在已经行小梁切除术的青光眼中。
Purpose: Secondary glaucoma and vitreous opacity with amyloid fibrils are the 2 major ocular complications of familial amyloid polyneuropathy (FAP). We investigated the feasibility of 25-gauge vitrectomy in excising the opaque vitreous into eyes that had already undergone trabeculectomy.Methods: For the purpose of vision recovery, 25-gauge vitrectomy was performed in 2 eyes with vitreous amyloidosis. Both eyes had undergone trabeculectomy to treat glaucoma secondary to FAR The survival of the filtration bleb after 25-gauge vitrectomy was also evaluated.Results: Vision improved dramatically on the next day after the 25-gauge vitrectomy that causes minimal damage to the eye. No apparent complications including failure of the filtration bleb have been observed throughout the follow-up period of 6 months.Conclusions: 25-gauge vitrectomy has a potential to become a therapy of choice to excise opaque vitreous with amyloid fibrils in FAP, especially in the glaucomatous eyes that have already undergone trabeculectomy.