Real-time in vivo color Doppler optical coherence tomography.
Real-time in vivo color Doppler optical coherence tomography.
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DOI：
10.1117/1.1428291
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发表时间：
2002
影响因子：
3.5
通讯作者：
A. Rollins;S. Yazdanfar;J. Barton;J. Izatt
中科院分区：
文献类型：
--
作者：
A. Rollins;S. Yazdanfar;J. Barton;J. Izatt
彩色多普勒光学相干断层扫描（CDOCT）是光学相干断层扫描（OCT）的功能扩展，可以对混浊介质中的血流进行成像。我们已经开发了一个CDOCT系统能够成像流在真实的时间。模拟信号的多普勒处理在时域中使用新颖的自相关技术在硬件中完成。这种多普勒处理方法与能够真实的实时成像的高速OCT系统兼容。使用该系统，我们展示了在组织模拟体模中以每秒四帧的速度使用CDOCT进行双向流动的横截面成像，该体模由在玻璃毛细管中流动的intraperoid溶液组成。作为体内血流实时成像的演示，我们以每秒8帧的速度对大鼠股动脉中的脉动血流进行成像。速度灵敏度，成像速度和速度测量范围的问题进行了讨论，以及实时CDOCT的潜在应用。
Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.