Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide
Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide
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DOI：
10.1161/01.hyp.37.4.1191
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发表时间：
2001-04-01
期刊：
影响因子：
8.3
通讯作者：
Granger, JP
中科院分区：
文献类型：
--
作者：
Alexander, BT;Kassab, SE;Granger, JP
一氧化氮（NO）合成的减少已被认为在妊娠高血压中起作用。我们最近报道了大鼠正常妊娠与全身NO生成和神经元和诱导NO合成酶的肾脏蛋白表达显著增加有关。本研究的目的是确定从妊娠第14天开始慢性降低子宫灌注压引起的妊娠高血压大鼠模型中，全身和肾脏NO的产生是否减少。子宫灌注压慢性降低导致动脉压升高20 ~ 25 mm Hg，肾血浆流量减少（< 23%），肾小球滤过少见（< 40%），但尿亚硝酸盐/硝酸盐排泄与对照妊娠大鼠无差异。相比之下，降低子宫灌注压对动脉压无明显影响。肾内皮(
A reduction in nitric oxide (NO) synthesis has been suggested to play a role in pregnancy-induced hypertension. We have recently reported that normal pregnancy in the rat is associated with significant increases in whole-body NO production and renal protein expression of neuronal and inducible NO synthase. The purpose of this study was to determine whether whole-body and renal NO production is reduced in a rat model of pregnancy-induced hypertension produced by chronically reducing uterine perfusion pressure starting at day 14 of gestation. Chronic reductions in uterine perfusion pressure resulted in increases in arterial pressure of 20 to 25 mm Hg, decreases in renal plasma flow (< 23%) and glomerular filtration rare (< 40%), but no difference in urinary nitrite/nitrate excretion relative to control pregnant rats. In contrast, reductions in uterine perfusion pressure in virgin rats resulted in no significant effects on arterial pressure. Renal endothelial (