PRE-CANCEROUS CONDITIONS AND EPITHELIAL DYSPLASIA IN THE STOMACH
PRE-CANCEROUS CONDITIONS AND EPITHELIAL DYSPLASIA IN THE STOMACH
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DOI：
10.1136/jcp.33.8.711
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
SERCKHANSSEN, A
中科院分区：
文献类型：
--
作者：
MORSON, BC;SOBIN, LH;SERCKHANSSEN, A
癌前病变和癌前病变是有区别的。前者是一种与癌症风险显著增加相关的临床状态，而癌前病变是一种组织病理学异常，其中癌症比明显正常的病变更容易发生。到目前为止，萎缩性胃炎、胃溃疡、恶性贫血、胃残肢、胃息肉和梅氏病都被认为是胃的癌前病变。其中，只有萎缩性胃炎、恶性贫血、胃残肢和某些类型的胃息肉现在可以被认为有任何真正显著的恶性潜能。常见的癌前病变是上皮异常增生，可发生在普通（小窝）胃上皮和肠化生中。给出了将胃上皮异常增生分为轻度、中度和重度的分级标准，并提请注意区分轻度异常增生中的炎症或再生变化以及严重异常增生中的粘膜内癌的问题。本文讨论了胃发育不良的临床和流行病学意义，并提出了进一步研究的建议。
A distinction can be made between a precancerous condition and a precancerous lesion. The former is a clinical state associated with a significantly increased risk of cancer, whereas a precancerous lesion is a histopathological abnormality in which cancer is more likely to occur than in its apparently normal counterpart. Up to the present time atrophic gastritis, gastric ulcer, pernicious anaemia, gastric stumps, gastric polyps, and Ménétrier's disease have all been considered as precancerous conditions and lesions of the stomach. Of these, only atrophic gastritis, pernicious anaemia, gastric stumps, and certain types of gastric polyp can now be regarded as having any really significant malignant potential. The precancerous lesion common to these is epithelial dysplasia which can occur in ordinary (foveolar) gastric epithelium as well as in intestinal metaplasia. The criteria for grading dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dysplasia. The clinical and epidemiological implications of gastric dysplasia are discussed with suggestions for further research.