Interhemispheric asymmetry of the human motor cortex related to handedness and gender
Interhemispheric asymmetry of the human motor cortex related to handedness and gender
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DOI：
10.1016/s0028-3932(99)00075-5
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Zilles, K
中科院分区：
文献类型：
--
作者：
Amunts, K;Jäncke, L;Zilles, K
大多数人是右撇子，无论是熟练的还是不熟练的活动，他们都喜欢用右手，但也有相当一部分人是混合型的，他们更喜欢用右手做一些动作，用左手做另一些动作。假设运动系统存在结构/功能上的相关性，我们测试了惯用右手者和惯用左手者以及惯用双手者的手部动作不对称是否与运动皮层的解剖不对称有关。采用活体磁共振形态学分析了103例健康受试者手皮层表征区中央沟深度的半球间不对称性。测试对象的手偏好和手的表现。正如预期的那样，惯用右手者、惯用左手者和惯用左手者之间的左右手表现差异显著，且与性别无关。男性惯用右手者的左脑中央沟明显比右脑深。解剖学上的不对称性从一贯的右撇子到一贯的左撇子显著减少。62%的惯用左手的人右脑中央沟比左脑深，但从整体上看，这种向右的不对称并不明显。女性未发现半球间不对称。因此，解剖上的不对称只在男性中与惯用手有关，而在女性中则没有，这表明手部运动的皮质组织存在性别差异。(C) 2000 Elsevier Science Ltd.版权所有。
Most people are right-handed, preferring the right hand for skilled as well as unskilled activities, but a notable proportion are mixed-handed, preferring to use the right hand for some actions and the left hand for others. Assuming a structural/functional correlation in the motor system we tested whether asymmetries in hand performance in consistent right and left handers as well as in mixed handers are associated with anatomical asymmetries in the motor cortex. In vivo MR morphometry was used for analyzing interhemispheric asymmetry in the depth of the central sulcus in the region of cortical hand representation of 103 healthy subjects. Subjects were tested both for hand preference and hand performance. As expected, left-right differences in hand performance differed significantly between consistent right, consistent left and mixed handers and were independent on gender. Male consistent right handers showed a significant deeper central sulcus on the left hemisphere than on the right. Anatomical asymmetries decreased significantly from male consistent right over mixed to consistent left handers. Sixty two per cent of consistent left handers revealed a deeper central sulcus on the right than on the left hemisphere, but for the group as a whole this rightward asymmetry was not significant. No interhemispheric asymmetry was found in females. Thus, anatomical asymmetry was associated with handedness only in males, but nor in females, suggesting sex differences in the cortical organization of hand movements. (C) 2000 Elsevier Science Ltd. All rights reserved.