Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease.
Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease.
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DOI：
10.1016/j.bone.2023.116808
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发表时间：
2023-05
期刊：
影响因子：
4.1
通讯作者：
C. Newman;Rachel K. Surowiec;Elizabeth A. Swallow;Corinne E. Metzger;Jieun Kim;Andrew A. Tomaschke;N. Chen;M. Allen;Joseph M. Wallace;S. Moe;Yu-chien Wu;P. Niziolek
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文献类型：
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作者：
C. Newman;Rachel K. Surowiec;Elizabeth A. Swallow;Corinne E. Metzger;Jieun Kim;Andrew A. Tomaschke;N. Chen;M. Allen;Joseph M. Wallace;S. Moe;Yu-chien Wu;P. Niziolek
慢性肾脏病（CKD）的特征是继发性甲状旁腺功能亢进和主要与皮质骨孔隙相关的髋部骨折风险增加。不幸的是，骨矿物质密度测量和高分辨率外周计算机断层扫描（HR-pQCT）成像的缺点，限制了他们在这些患者中的效用。超短回波时间磁共振成像（UTE-MRI）有可能通过提供皮质孔隙度的替代评估来克服这些局限性。本研究的目的是确定UTE-MRI是否可以检测已建立的CKD大鼠模型中孔隙度的变化。Cy/+大鼠（n= 11），已建立的CKD-MBD动物模型，以及它们的正常同窝仔（n= 12）在30和35周龄（其接近人类晚期肾病）时使用微计算机断层扫描（microCT）和UTE-MRI成像。在胫骨远端和股骨近端获得图像。使用根据microCT成像计算的孔隙率百分比（Pore%）和根据UTE-MRI计算的孔隙率指数（PI）评估皮质孔隙率。Cy/+大鼠在35周时两个骨骼部位的孔隙率均高于正常大鼠（胫骨= 7.13%+/− 5.59% vs.0.51%+/− 0.09%，股骨= 19.99%+/− 7.72% vs.2.72%+/− 0.32%）。在30周龄时，它们的胫骨远端PI也更大（0.47 +/− 0.06vs.0.40 +/− 0.08）。然而，仅在35周龄时股骨近端中的孔隙%和PI相关（ρ = 0.929，斯皮尔曼）。这些microCT结果与利用microCT成像在该动物模型中的先前研究一致。UTE-MRI结果不一致，导致与microCT成像的可变相关性，这可能与较高磁场强度下的次优结合水和孔隙水区分有关。尽管如此，UTE-MRI仍然可以提供一种额外的临床工具来评估CKD患者的骨折风险，而无需使用电离辐射。
Chronic kidney disease (CKD) is characterized by secondary hyperparathyroidism and an increased risk of hip fractures predominantly related to cortical porosity. Unfortunately, bone mineral density measurements and high-resolution peripheral computed tomography (HR-pQCT) imaging have shortcomings that limit their utility in these patients. Ultrashort echo time magnetic resonance imaging (UTE-MRI) has the potential to overcome these limitations by providing an alternative assessment of cortical porosity. The goal of the current study was to determine if UTE-MRI could detect changes in porosity in an established rat model of CKD.Cy/+ rats (n= 11), an established animal model of CKD-MBD, and their normal littermates (n= 12) were imaged using microcomputed tomography (microCT) and UTE-MRI at 30 and 35 weeks of age (which approximates late-stage kidney disease in humans). Images were obtained at the distal tibia and the proximal femur. Cortical porosity was assessed using the percent porosity (Pore%) calculated from microCT imaging and the porosity index (PI) calculated from UTE-MRI. Correlations between Pore% and PI were also calculated.Cy/+ rats had higher Pore% than normal rats at both skeletal sites at 35 weeks (tibia = 7.13 % +/− 5.59 %vs.0.51 % +/− 0.09 %, femur = 19.99 % +/− 7.72 %vs.2.72 % +/− 0.32 %). They also had greater PI at the distal tibia at 30 weeks of age (0.47 +/− 0.06vs.0.40 +/− 0.08). However, Pore% and PI were only correlated in the proximal femur at 35 weeks of age (ρ = 0.929, Spearman).These microCT results are consistent with prior studies in this animal model utilizing microCT imaging. The UTE-MRI results were inconsistent, resulting in variable correlations with microCT imaging, which may be related to suboptimal bound and pore water discrimination at higher magnetic field strengths. Nevertheless, UTE-MRI may still provide an additional clinical tool to assess fracture risk without using ionizing radiation in CKD patients.