Brief Report: "Allergic Symptoms" in Children with Autism Spectrum Disorders. More than Meets the Eye?
Brief Report: "Allergic Symptoms" in Children with Autism Spectrum Disorders. More than Meets the Eye?
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DOI：
10.1007/s10803-010-1171-z
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发表时间：
2011-11-01
影响因子：
3.9
通讯作者：
Theoharides, Theoharis C.
中科院分区：
文献类型：
--
作者：
Angelidou, Asimenia;Alysandratos, Konstantinos-Dionysios;Theoharides, Theoharis C.
许多患有自闭症谱系障碍（ASD）的儿童都有家族和/或个人的“过敏性皮肤病”史，通常没有阳性皮肤或RAST测试。这些症状可能表明肥大细胞激活的非过敏性触发。此外，患有肥大细胞增多症或肥大细胞活化综合征（MCAS）的儿童，一种以许多器官中活化肥大细胞数量增加为特征的罕见疾病谱，似乎患有ASD的比率（1/10儿童）比一般人群（1/100儿童）高10倍。肥大细胞由过敏、感染、环境和应激相关的触发物激活，特别是围产期，会释放促炎和神经毒性分子。我们推测这些可能会破坏肠-血-脑屏障，从而导致脑炎症和ASD发病机制。增加的肥大细胞反应性可以定义至少一个ASD受试者亚组，其可以从肥大细胞活化的抑制中受益。
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation.