Usefulness of S100A12 as a prognostic biomarker for adverse events in patients with heart failure
Usefulness of S100A12 as a prognostic biomarker for adverse events in patients with heart failure
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DOI：
10.1016/j.clinbiochem.2014.11.016
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发表时间：
2015-03-01
影响因子：
2.8
通讯作者：
He, Kun-Lun
中科院分区：
文献类型：
--
作者：
He, Yun-Yun;Yan, Wei;He, Kun-Lun
目的：S100A12被认为是一种新的粒细胞炎症关键因子。本研究旨在探讨S100A12基因与慢性心力衰竭的关系。设计与方法：慢性心力衰竭患者177例，非心力衰竭患者66例。测定所有受试者的血浆S100A12和超敏C反应蛋白(hs-CRP)水平。结果：心力衰竭患者血浆S100A12水平显著高于对照组(P<；0.001)，且与hs-C反应蛋白水平呈正相关(r=0.316，P<；0.001)。MCE患者的S100A12水平也高于非MCE患者。按四分位数分层，随着血浆S100A12水平的升高，MCE的发生率增加(Q4vsQ1，P=0.015)。COX比例风险回归分析显示，S100A12是心力衰竭患者发生心力衰竭的独立危险因素(P=0.009)。结论：S100A12是心力衰竭的潜在生物标志物，可为预测心力衰竭患者心脑血管病变提供重要信息。(C)2014年加拿大临床化学家学会。爱思唯尔公司出版。版权所有，
Objectives: S100A12 has been proposed as a novel pivotal factor in inflammation produced by granulocytes. The purpose of this study was to investigate the relationship between S100A12 and chronic heart failure (CHF).Design and methods: One hundred and seventy-seven patients with CHF and 66 subjects without CHF were included in this study. Plasma levels of S100A12 and high sensitivity C-reactive protein (hs-CRP) were measured in all participants. After a follow-up period of 18 months for CHF patients, major cardiovascular events (MCE), including cardiac death and rehospitalization for heart failure, were recorded.Results: Plasma levels of S100A12 were significantly higher in CHF patients than in control subjects (P < 0.001) and positively correlated with hs-CRP (r = 0.316, P < 0.001). S100A12 levels were also higher in MCE patients than in MCE-free patients. The occurrence of MCE increased with advancing plasma S100A12 levels by stratification according to quartiles (Q4 vs Q1, P = 0.015). Cox proportional hazards regression analysis revealed that S100A12 was an independent risk factor for MCE in CHF patients (P = 0.009).Conclusions: S100A12 is a potential biomarker of CHF that may provide important information regarding the prediction of MCE in patients with CHF. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved,