Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries.
Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries.
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DOI：
10.1155/2012/216450
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发表时间：
2012
影响因子：
3
通讯作者：
Ji C
中科院分区：
文献类型：
--
作者：
Ji C
酒精很容易在血液中分布在整个身体，并穿过生物膜，这几乎影响了细胞内的所有生物过程。过量饮酒可引起许多病理性应激反应，其中一部分是内质网（ER）应激反应。内质网应激是一种未折叠/错误折叠的蛋白质在内质网中积累的状况，导致主要器官如肝脏、胰腺、心脏和大脑的酒精性疾病。触发酒精性内质网应激反应的潜在机制与酒精代谢直接或间接相关，包括毒性乙醛和同型半胱氨酸、氧化应激、钙或铁稳态的扰动、S-腺苷甲硫氨酸与S-腺苷同型半胱氨酸比率的改变以及异常表观遗传修饰。预期中断ER应激触发物对酒精性疾病具有治疗益处。
Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell. Excessive alcohol consumption induces numerous pathological stress responses, part of which is endoplasmic reticulum (ER) stress response. ER stress, a condition under which unfolded/misfolded protein accumulates in the ER, contributes to alcoholic disorders of major organs such as liver, pancreas, heart, and brain. Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. Interruption of the ER stress triggers is anticipated to have therapeutic benefits for alcoholic disorders.