Infants of Women with Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels
Infants of Women with Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels
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DOI：
10.1210/jc.2009-2651
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发表时间：
2010-05-01
影响因子：
5.8
通讯作者：
Dunaif, Andrea
中科院分区：
文献类型：
--
作者：
Anderson, Helen;Fogel, Naomi;Dunaif, Andrea
背景：产前雄激素过多可在哺乳动物中引起多囊卵巢综合征（PCOS）的表型模拟。回顾性研究表明，有患PCOS风险的女孩出生体重较低，前瞻性研究表明多囊卵巢综合征女性的小于胎龄儿患病率增加。
目的：本研究的目的是确定多囊卵巢综合征女性的婴儿是否出生体重降低或宫内雄激素水平升高。
设计：这是一项前瞻性病例对照研究。
参与者：39名多囊卵巢综合征女性和31名对照女性及其婴儿参与了研究。
主要观察指标：测量出生体重以及脐带血混合睾酮、雄烯二酮（A）、脱氢表雄酮、17 - 羟孕酮、雌二醇（E2）和双氢睾酮水平。
结果：平均出生体重无差异，但多囊卵巢综合征组大于胎龄儿的患病率显著增加。脐带血E2和A水平较低（P < 0.05），但多囊卵巢综合征女性的女性后代与对照后代相比，睾酮与E2的比值无差异。多囊卵巢综合征男性后代与对照后代的E2和A水平无差异。多囊卵巢综合征男性或女性后代与各自对照组相比，17 - 羟孕酮或其他雄激素水平无差异。
结论：多囊卵巢综合征女性的婴儿更有可能是大于胎龄儿。患病女性的女性后代脐带血A水平较低；与女性对照后代相比，其他脐带血雄激素水平无差异。多囊卵巢综合征患者的脐带血E2水平也显著降低，睾酮与E2的比值无差异，这表明胎儿或胎盘的类固醇生成减少。（《临床内分泌与代谢杂志》2010年95卷2180 - 2186页）
Context: Prenatal androgen excess can cause a phenocopy of polycystic ovary syndrome (PCOS) in mammals. Retrospective studies have suggested that girls at risk for PCOS have low birth weight, and prospective studies have suggested an increased prevalence of small-for-gestational-age offspring in women with PCOS.Objective: The objective of the study was to determine whether infants of women with PCOS have reduced birth weight or increased intrauterine androgen levels.Design: This was a prospective case-control study.Participants: Thirty-nine PCOS and 31 control women and their infants participated in the study.Main Outcome Measures: Birth weight and mixed cord blood testosterone, androstenedione (A), dehydroepiandrosterone, 17-hydroxyprogesterone, estradiol (E2), and dihydrotestosterone levels were measured.Results: Mean birth weight did not differ, but there was a significant increase in the prevalence of large-for-gestational-age infants in the PCOS group. Cord blood E2 and A levels were lower (P < 0.05), but testosterone to E2 ratios did not differ in female PCOS compared with control offspring. There was no difference in E2 and A levels in the male PCOS and control offspring. There was no difference in 17-hydroxyprogesterone or other androgen levels in either male or female PCOS offspring compared with their respective control group.Conclusion: Infants of women with PCOS were more likely to be large for gestational age. Female offspring of affected women have lower cord blood A levels; other cord blood androgen levels do not differ compared with female control offspring. Cord blood E2 levels are also significantly decreased in PCOS, without any difference in the testosterone to E2 ratio, suggesting decreased fetal or placental production of steroids. (J Clin Endocrinol Metab 95: 2180-2186, 2010)