The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD
The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD
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DOI：
10.1038/s41598-020-60096-1
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发表时间：
2020-02-21
影响因子：
4.6
通讯作者：
Kim, Yoshiharu
中科院分区：
文献类型：
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作者：
Hori, Hiroaki;Itoh, Mariko;Kim, Yoshiharu
记忆异常被认为是创伤后应激障碍（PTSD）的核心特征。试图量化创伤后应激障碍中这种记忆功能障碍的研究报告说，患有这种疾病的个体表现出对负面材料的选择性记忆偏见。脑源性神经营养因子（BDNF）Val 66 Met多态性的低表达Met等位基因与PTSD的病因学和记忆异常相关。因此，BDNF Val 66 Met多态性可能会调节PTSD和记忆偏差之间的关系。在这里，我们研究了50名平民妇女与创伤后应激障碍和70名非创伤暴露的健康对照妇女的这种关联。所有受试者的BDNF Val 66 Met（rs6265）多态性基因分型。负性记忆偏差采用再认记忆任务进行评估。与对照组相比，患者表现出显着更大的负记忆偏差。在患者中，负性记忆偏差随着Met等位基因数量的增加而显著增加;而在对照组中没有观察到显著的关系。进一步的成对分析显示，具有Met等位基因的患者比对照组具有显着更大的负记忆偏差。这些结果表明，PTSD和负性记忆偏差之间的关系可以通过BDNF Val 66 Met多态性来调节。这一多态性与PTSD患者记忆异常之间的关系尚需进一步研究。
Memory abnormalities are considered a core feature of posttraumatic stress disorder (PTSD). Studies attempting to quantify such memory dysfunction in PTSD have reported that individuals with this disorder exhibit selective memory bias toward negative material. The low expression Met allele of brainderived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with the aetiology of PTSD and with memory abnormalities. It is therefore possible that the BDNF Val66Met polymorphism can moderate the relationship between PTSD and memory bias. Here we examined this association in 50 civilian women with PTSD and 70 non-trauma-exposed healthy control women. All subjects were genotyped for the BDNF Val66Met (rs6265) polymorphism. Negative memory bias was assessed using a recognition memory task. Patients showed significantly greater negative memory bias compared to controls. In patients, negative memory bias significantly increased with increasing numbers of Met alleles; while no significant relationship was seen in controls. Further pairwise analyses revealed that patients with the Met allele had significantly greater negative memory bias than controls. These results suggest that the relationship between PTSD and negative memory bias can be moderated by the BDNF Val66Met polymorphism. More studies are needed to further clarify the relationship between this polymorphism and memory abnormalities in PTSD.