The Role of microRNAs in the Tumorigenesis of Ovarian Cancer.
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer.
复制标题
microRNA在卵巢癌的肿瘤发生中的作用。
DOI：
10.3389/fonc.2013.00153
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发表时间：
2013
影响因子：
4.7
通讯作者：
Croce CM
中科院分区：
文献类型：
--
作者：
Di Leva G;Croce CM
上皮性卵巢癌(EOC)是一种复杂的疾病，具有多种组织亚型。对这种人类恶性肿瘤的细胞和分子生物学的了解已经取得了重大进展，然而，自30多年前引入基于铂的治疗以来，卵巢癌女性患者的存活率变化很小。自2006年以来，越来越多的研究表明microRNAs(MiRNAs)在卵巢癌的发生中起着重要的作用。一些miRNA图谱研究表明，它们与卵巢癌的不同方面(肿瘤亚型、分期、组织学分级、预后和治疗耐药)有关，并指出miRNAs在卵巢癌的发生和发展中起着关键作用。在这篇综述中，我们讨论了目前有关miRNAs在卵巢癌中表达调控的证据的积累，以及它们在诊断、预后和预测治疗反应中的作用。鉴于这种疾病的异质性，通过将miRNAs参与EOC的最新见解转化为将对卵巢癌的治疗产生重大影响的新的靶向治疗，很可能还可以提高长期存活率。
Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of women with EOC has changed little since platinum-based-treatment was introduced more than 30 years ago. Since 2006, an increasing number of studies have indicated an essential role for microRNAs (miRNAs) in ovarian-cancer tumorigenesis. Several miRNA profiling studies have shown that they associate with different aspects of ovarian cancer (tumor subtype, stage, histological grade, prognosis, and therapy resistance) and pointed to a critical role for miRNAs in the pathogenesis and progression of EOC. In this review, we discuss the current data concerning the accumulating evidence of the modulated expression of miRNAs in EOC, their role in diagnosis, prognosis, and prediction of response to therapy. Given the heterogeneity of this disease, it is likely that increases in long-term survival might be also achieved by translating the recent insights of miRNAs involvement in EOC into novel targeted therapies that will have a major impact on the management of ovarian cancer.