Motion of red blood cells in capillaries with variable cross-sections.
Motion of red blood cells in capillaries with variable cross-sections.
复制标题
红细胞在具有可变横截面的毛细血管中的运动。
DOI：
10.1115/1.2796041
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hsu,R
中科院分区：
文献类型：
--
作者：
Secomb,TW;Hsu,R
红细胞在穿过活组织中的微血管时经历连续变形。与相应的均匀玻璃管相比，这可能有助于在活微血管中观察到的更高的血流阻力。我们使用一个理论模型来模拟单列运动的红细胞通过毛细血管的可变截面，假设轴对称的几何形状。计算中考虑了细胞膜剪切粘度和弹性的影响，但忽略了弯曲阻力的影响。润滑理论被用来描述周围等离子体的流动。当红细胞遇到毛细血管变窄的区域时，由于膜粘度和润滑层变窄，额外的能量被耗散，从而增加了流动阻力。在具有周期性收缩（直径在5 μm和4 μm之间变化）的血管中预测的细胞运动阻力大约是直径为4.5 μm的均匀血管中的两倍。短暂的红细胞变形的影响可能会显着地促进活微血管中的血流阻力。
Red blood cells undergo continual deformation when traversing microvessels in living tissues. This may contribute to higher resistance to blood flow observed in living microvessels, compared with that in corresponding uniform glass tubes. We use a theoretical model to simulate single-file motion of red cells though capillaries with variable cross-sections, assuming axisymmetric geometry. Effects of cell membrane shear viscosity and elasticity are included, but bending resistance is neglected. Lubrication theory is used to describe the flow of surrounding plasma. When a red cell encounters a region of capillary narrowing, additional energy is dissipated, due to membrane viscosity, and due to narrowing of the lubrication layer, increasing the flow resistance. Predicted resistance to cell motion in a vessel with periodic constrictions (diameter varying between 5 μm and 4 μm) is roughly twice that in a uniform vessel with diameter 4.5 μm. Effects of transient red cell deformations may contribute significantly to blood flow resistance in living microvessels.