Animal models for the study of HBV replication and its variants
Animal models for the study of HBV replication and its variants
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DOI：
10.1016/s1386-6532(05)80011-3
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发表时间：
2005-12-01
影响因子：
8.8
通讯作者：
Petersen, J.
中科院分区：
文献类型：
--
作者：
Dandri, M.;Volz, T. K.;Petersen, J.
通过对禽类和哺乳动物HBV相关病毒的鉴定，B型肝炎病毒的研究取得了巨大进展，这为在自然宿主中进行研究提供了充足的机会。然而，这些天然宿主都不属于常用的实验室动物，并且携带HBV转基因的各种小鼠品系的开发为研究病毒致病机制提供了独特的机会。此外，需要在含有HBV-容许肝细胞的系统中进行感染研究，最近导致研究人员创建新的具有挑战性的HBV感染的人-小鼠嵌合体模型。在这篇综述中，我们将概述目前在嗜肝DNA病毒研究中可用的动物模型的类型。(C)2005 Elsevier B. V.保留所有权利。
Enormous progresses in hepatitis B virus research have been made through the identification of avian and mammalian HBV-related viruses, which offer ample opportunities for studies in naturally occurring hosts. However, none of these natural hosts belongs to the commonly used laboratory animals, and the development of various mouse strains carrying HBV transgenes offered unique opportunities to investigate some mechanisms of viral pathogenesis. Furthermore, the need to perform infection studies in a system harbouring HBV-permissive hepatocytes has lately led researchers to create new challenging human-mouse chimera models of HBV infection. In this review, we will overview the type of animal models currently available in hepadnavirus research. (C) 2005 Elsevier B.V. All rights reserved.