N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
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DOI：
10.1093/eurheartj/ehp420
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发表时间：
2010-01-01
影响因子：
39.3
通讯作者：
de Zeeuw, Dick
中科院分区：
文献类型：
--
作者：
Linssen, Gerard C. M.;Bakker, Stephan J. L.;de Zeeuw, Dick
目的利钠肽包括N末端B型利钠肽前体（NT-proBNP）是心力衰竭的生物标志物。然而，其在一般人群中的预后价值还不太确定。我们的研究的目的是调查NT-proBNP的死亡和心血管（CV）事件在一般population.Methods和结果的预后特性在人口为基础的预防肾和血管终末期疾病（PREVEND）的研究，8383例受试者进行了前瞻性随访，中位数为7.5年。有4181名（49.9%）男性和4202名（50.1%）女性，平均年龄为49.3 ± 12.7岁（范围28-75岁）。基线时中位NT-proBNP为37.7 pg/mL（IQR 16.8-73.8）。437例（5.2%）受试者发生全因死亡，557例（6.6%）CV事件。血浆NT-proBNP水平升高与事件发生率升高相关。当校正年龄、性别和其他相关协变量后，NT-proBNP每增加一倍，全因死亡风险增加22%（P < 0.001），心血管事件风险增加16%（P <0.001.Conclusion在这个大型社区队列中，血浆NT-proBNP是死亡和多种心血管事件的强预测因子。
Aims Natriuretic peptides including N-terminal pro-B-type natriuretic peptide (NT-proBNP) are established biomarkers in heart failure. However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population.Methods and results In the population-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study, 8383 subjects were prospectively followed for a median period of 7.5 years. There were 4181 (49.9%) mates and 4202 (50.1%) females, mean age was 49.3 +/- 12.7 years (range 28-75). Median NT-proBNP at baseline was 37.7 pg/mL (IQR 16.8-73.8). All-cause death occurred in 437 (5.2%) subjects and there were 557 (6.6%) CV events. Higher levels of plasma NT-proBNP were related to higher event rates. When adjusted for age, gender, and other relevant covariates, each doubling of NT-proBNP remained significantly associated with a 22% increased risk for all-cause mortality (P < 0.001) and a 16% increased risk of CV events (P < 0.001).Conclusion In this large community-based cohort, plasma NT-proBNP was a strong predictor of death and a wide range of CV events.