Evaluation of a bioabsorbable physical barrier for guided bone regeneration. Part II. Material and a bone replacement graft.
Evaluation of a bioabsorbable physical barrier for guided bone regeneration. Part II. Material and a bone replacement graft.
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用于引导骨再生的生物可吸收物理屏障的评估。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
R. Sánchez
中科院分区：
文献类型：
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作者：
J. Mellonig;M. Nevins;R. Sánchez
由丙交酯和乙交酯共聚物组成的原型生物可吸收物理屏障用于治疗引导骨再生手术中的骨缺损的评价的第I部分表明，原型生物可吸收物理屏障不具备足够的空间制造特性，以防止屏障塌陷到缺损中或贴靠钛植入物的螺纹。第II部分的目的是评价这种生物可吸收物理屏障与支持材料的组合，以防止屏障塌陷。三只狗的下颌后牙被拔出，并允许愈合3个月。这产生了局部牙槽嵴缺损，颊舌宽度狭窄。在每只狗的左右下颌骨中放置六个钛螺纹种植体，以产生非空间制造开裂型缺损。每只动物中的两个缺损随机使用原型生物可吸收物理屏障和脱钙冻干同种异体骨进行治疗;两个缺损使用非生物可吸收膨胀聚四氟乙烯屏障和脱钙冻干同种异体骨进行治疗;每个缺损单独使用原型生物可吸收物理屏障或通过皮瓣入路（无屏障或骨替代移植物）进行治疗。结果表明，生物可吸收和非生物可吸收防粘连医用膜与脱钙冻干同种异体骨组合产生的新骨量相当，骨-植入物接触百分比、高度、宽度和面积相当。单独使用原型生物可吸收物理屏障或不使用屏障治疗的缺损显示出不利的结果。建议在治疗非空间形态的缺损时使用骨替代移植物。
Part I of the evaluation of a prototype bioabsorbable physical barrier composed of a copolymer of lactide and glycolide for treatment of bone defects in the guided bone regeneration procedure indicated that the prototype bioabsorbable physical barrier did not possess sufficient spacemaking characteristics to prevent collapse of the barrier into the defect or against the threads of the titanium implants. The purpose of Part II was to evaluate this bioabsorbable physical barrier in combination with a supporting material to prevent barrier collapse. Posterior mandibular teeth in three dogs were extracted and allowed to heal for 3 months. This produced localized alveolar ridge defects with a narrow buccolingual width. Six titanium threaded implants were placed in the right and left mandibles of each dog so that nonspacemaking dehiscencetype defects were produced. Two defects in each animal were randomly treated with the prototype bioabsorbable physical barrier and decalcified freeze-dried bone allograft; two defects were treated with a nonbioabsorbable expanded polytetrafluoroethylene barrier with decalcified freeze-dried bone allograft; and one defect each was treated with prototype bioabsorbable physical barrier alone or by flap access with no barrier or bone replacement graft. The results demonstrated that both the bioabsorbable and the nonbioabsorbable barrier combined with decalcified freeze-dried bone allograft produce comparable amounts of new bone with percent bone-to-implant contact, height, width, and area. Defects treated with the prototype bioabsorbable physical barrier alone or no barrier demonstrated unfavorable results. It is suggested that a bone replacement graft is indicated when treating defects with a nonspacemaking morphology.