Metabolic diseases and sex hormone levels affect differently in the development of cardiovascular and cerebrovascular diseases in elderly males
Metabolic diseases and sex hormone levels affect differently in the development of cardiovascular and cerebrovascular diseases in elderly males
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DOI：
10.3109/13685538.2014.1002082
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Y. Gong;Xiaoling Cheng;Chunlin Li;Jian Li;Mengmeng Jin;Banruo Sun;H. Tian
中科院分区：
文献类型：
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作者：
Y. Gong;Xiaoling Cheng;Chunlin Li;Jian Li;Mengmeng Jin;Banruo Sun;H. Tian
摘要目的：这项单中心横断面研究旨在调查老年男性血管疾病的代谢和性腺危险因素。方法：对337名60-90岁的老年人进行筛查，筛选出合格人群。采用交叉表分析的比值比（OR）和Logistic回归分析的exp（B）评价血管性疾病的危险因素。采用Logistic回归方程的R2值对血管性疾病Logistic回归模型的拟合优度进行估计。结果：高血压使老年男性心血管疾病（CAVD）的风险增加约3倍。代谢性疾病的数量也与CAVD的风险增加相关;一种异常的存在使风险增加约62%。脑血管病的发生与代谢综合征和性激素水平密切相关，两者单独作用和联合作用的解释率分别为13.2%、12.55%和28.5%。C肽可能是代谢综合征影响CEVD的潜在机制。C肽= 2.43 U/L和FE 2 = 0.66是受试者工作特征（ROC）分析的切点。结论：代谢性疾病和性激素在CAVD和CEVD的发生发展中起着不同的作用，应根据老年男性CAVD和CEVD的危险性，采取不同的血管保护措施。
Abstract Objective: This single-centre cross-sectional study aimed to investigate the metabolic and gonadal risk factors of vascular diseases in elderly males. Methods: After screening, 337 subjects aged 60–90 were found to be qualified. Odds ratios (ORs) in cross-table analyses and exp(B) in logistic regression analyses were used to evaluate the vascular risk of dependent factors. R2 of logistic regression equation was used to estimate the goodness-of-fit of vascular diseases logistic regression models. Results: Hypertension increased the risk of cardiovascular disease (CAVD) in elderly men approximately 3-fold. The number of metabolic diseases also correlated with incremental risks of CAVD; presence of one abnormality approximately increases the risk approximately 62%. Cerebrovascular disease (CEVD) development was closely associated with both metabolic syndrome and sex hormone levels; their explanation effects of single action and combined action were 13.2%, 12.55% and 28.5%. C-peptide might be the underlying mechanism of the metabolic syndrome’s effect on CEVD. C-peptide = 2.43 U/L and FE2 = 0.66 were the tangent points in receiver operating characteristic (ROC) analyses. Conclusions: Metabolic diseases and sex hormones play different roles in the development of CAVD and CEVD, the methods for vascular protection in elderly men should be promoted differently according to the their risks of CAVD and CEVD.