Unravelling tumour heterogeneity using next-generation imaging: radiomics, radiogenomics, and habitat imaging.
Unravelling tumour heterogeneity using next-generation imaging: radiomics, radiogenomics, and habitat imaging.
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DOI：
10.1016/j.crad.2016.09.013
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发表时间：
2017-01
影响因子：
2.6
通讯作者：
Vargas HA
中科院分区：
文献类型：
--
作者：
Sala E;Mema E;Himoto Y;Veeraraghavan H;Brenton JD;Snyder A;Weigelt B;Vargas HA
已在组织学和遗传水平上观察到癌症中的肿瘤异质性，据报道，肿瘤内遗传异质性水平的增加与不良临床结局相关。本文综述了放射组学，放射基因组学和栖息地成像的概述，并探讨了这些新出现的领域在评估肿瘤异质性及其影响。它回顾了放射组学和放射基因组学在辅助诊断癌症疾病和确定癌症侵袭性方面的潜在价值。这篇综述讨论了如何放射基因组学分析可以进一步用于指导治疗个别肿瘤的药物反应和潜在的治疗耐药性预测，并探讨其在发展放射组学作为肿瘤学结果的生物标志物的作用。最后，它概述了当今这些新兴领域的障碍，包括可重复性，验证需求，成像分析标准化，数据共享和临床可翻译性，并为实现精确肿瘤学的这些挑战提供了潜在的解决方案。
Tumour heterogeneity in cancers has been observed at the histological and genetic levels, and increased levels of intra-tumour genetic heterogeneity have been reported to be associated with adverse clinical outcomes. This review provides an overview of radiomics, radiogenomics, and habitat imaging, and examines the use of these newly emergent fields in assessing tumour heterogeneity and its implications. It reviews the potential value of radiomics and radiogenomics in assisting in the diagnosis of cancer disease and determining cancer aggressiveness. This review discusses how radiogenomic analysis can be further used to guide treatment therapy for individual tumours by predicting drug response and potential therapy resistance and examines its role in developing radiomics as biomarkers of oncological outcomes. Lastly, it provides an overview of the obstacles in these emergent fields today including reproducibility, need for validation, imaging analysis standardisation, data sharing and clinical translatability and offers potential solutions to these challenges towards the realisation of precision oncology.
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NCI研讨会报告：将成像表型与基因组学特征相关联的临床和计算要求。
影响因子：
5
作者：
Colen, Rivka;Foster, Ian;Gatenby, Robert;Giger, Mary Ellen;Gillies, Robert;Gutman, David;Heller, Matthew;Jain, Rajan;Madabhushi, Anant;Madhavan, Subha;Napel, Sandy;Rao, Arvind;Saltz, Joel;Tatum, James;Verhaak, Roeland;Whitman, Gary
通讯作者：
Whitman, Gary
影响因子：
3.7
作者：
Grove O;Berglund AE;Schabath MB;Aerts HJ;Dekker A;Wang H;Velazquez ER;Lambin P;Gu Y;Balagurunathan Y;Eikman E;Gatenby RA;Eschrich S;Gillies RJ
通讯作者：
Gillies RJ
DOI：
10.1073/pnas.1505935112
发表时间：
2015-11-17
影响因子：
11.1
作者：
Fehr, Duc;Veeraraghavan, Harini;Deasy, Joseph O.
通讯作者：
Deasy, Joseph O.
影响因子：
3
作者：
Chen, Chun-Ku;Wu, Hung-Ta;Chen, Wei-Ming
通讯作者：
Chen, Wei-Ming
影响因子：
4.4
作者：
Clark, Kenneth;Vendt, Bruce;Prior, Fred
通讯作者：
Prior, Fred