Cumulative stress in research animals: Telomere attrition as a biomarker in a welfare context?
Cumulative stress in research animals: Telomere attrition as a biomarker in a welfare context?
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DOI：
10.1002/bies.201500127
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发表时间：
2016-02
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影响因子：
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通讯作者：
Bateson M
中科院分区：
文献类型：
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作者：
Bateson M
目前，由于缺乏评估终生经验的客观方法，在改善动物福利方面的进展受到限制。我建议端粒磨损，生物学年龄的细胞生物标志物，提供了累积经验的分子测量，可用于评估饲养制度和/或实验程序对非人类动物的福利影响。我回顾了来自人类的证据，即端粒磨损以累积和剂量依赖的方式被负面经历加速，但这种磨损可以通过积极的生活方式干预来减轻甚至逆转。来自非人类动物的证据表明，尽管端粒生物学存在一些特定差异，但应激诱导的端粒磨损是一种强烈的现象，发生在包括小鼠和鸡在内的一系列物种中。我的结论是，端粒磨损显然整合了积极和消极的经验，在一个可访问的共同货币，很容易转化为新的物种-圣杯的累积福利指标。
Progress in improving animal welfare is currently limited by the lack of objective methods for assessing lifetime experience. I propose that telomere attrition, a cellular biomarker of biological age, provides a molecular measure of cumulative experience that could be used to assess the welfare impact of husbandry regimes and/or experimental procedures on non‐human animals. I review evidence from humans that telomere attrition is accelerated by negative experiences in a cumulative and dose‐dependent manner, but that this attrition can be mitigated or even reversed by positive life‐style interventions. Evidence from non‐human animals suggests that despite some specific differences in telomere biology, stress‐induced telomere attrition is a robust phenomenon, occurring in a range of species including mice and chickens. I conclude that telomere attrition apparently integrates positive and negative experience in an accessible common currency that translates readily to novel species – the Holy Grail of a cumulative welfare indicator.