Omnidirectional Printing of 3D Microvascular Networks
Omnidirectional Printing of 3D Microvascular Networks
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DOI：
10.1002/adma.201004625
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发表时间：
2011-06-24
影响因子：
29.4
通讯作者：
Lewis, Jennifer A.
中科院分区：
文献类型：
--
作者：
Wu, Willie;DeConinck, Adam;Lewis, Jennifer A.
三维仿生微血管网络几乎任意设计的图案是由无组织的有机油墨的全向印刷到光聚合水凝胶基质。这种新颖的方法关键在于调整易失性油墨的化学和流变特性，以及光聚合水凝胶储层和流体填料。这些基于水凝胶的微血管结构可能在3D细胞培养、组织工程、器官建模和自主愈合中找到潜在的应用。
3D biomimetic microvascular networks of nearly arbitrary design are patterned by omnidirectional printing of a fugitive organic ink into a photopolymerizable hydrogel matrix. This novel approach hinges critically on tailoring the chemical and rheological properties of the fugitive ink as well as the photopolymerizable hydrogel reservoir and fluid filler. These hydrogel-based, microvascular constructs may find potential application in 3D cell culture, tissue engineering, organ modeling, and autonomic healing.