LACK OF DESENSITIZATION OF CATECHOLAMINE-INDUCED LIPOLYSIS IN FAT-CELLS FROM TRAINED AND SEDENTARY WOMEN AFTER PHYSICAL EXERCISE
LACK OF DESENSITIZATION OF CATECHOLAMINE-INDUCED LIPOLYSIS IN FAT-CELLS FROM TRAINED AND SEDENTARY WOMEN AFTER PHYSICAL EXERCISE
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DOI：
10.1210/jcem-67-5-1011
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发表时间：
1988-11-01
影响因子：
5.8
通讯作者：
LAFONTAN, M
中科院分区：
文献类型：
--
作者：
CRAMPES, F;BEAUVILLE, M;LAFONTAN, M
设计了一项研究以评估已知促进交感神经系统激活的一段时间的体育锻炼（100分钟;最大有氧功率的60%）是否对人脂肪细胞对儿茶酚胺和β-肾上腺素的响应性具有功能性影响。激动剂在一段时间的运动之前和之后，测量了具有相似体重指数值[20.4 . ±.]的训练和久坐妇女的分离的sc脂肪细胞的脂解活性。0.5 (.+-. SE）和21.3 .+-。0.5 kg/m2]和相等的平均脂肪细胞体积（0.216 ± 0.216）。0.022 vs. 0.278 pm 0.026 nL）。在运动前，与久坐妇女的脂肪细胞相比，受过训练的妇女的脂肪细胞对儿茶酚胺和β-肾上腺素具有更大的脂解反应性。激动剂;此外，双丁酰cAMP对训练妇女的脂肪细胞具有更大的脂解效率。这些结果表明，久坐不动和训练有素的妇女的脂肪细胞的反应性的差异是由于功能的差异在后受体水平的脂肪分解级联。脂肪分解（β-两组脂肪细胞的抗脂肪分解（α 2-肾上腺素能）和抗脂肪分解（α 2-肾上腺素能）反应在体力活动期后没有变化。这些结果表明，无论受试者的身体状况如何，β-葡聚糖的脱敏作用都是有效的。并且α 2-肾上腺素能反应性在促进交感神经系统的生理激活的一段时间的强烈身体活动后不发生。
A study wad designed to assess whether a period of physical exercise (100 min; 60% of maximal aerobic power), known to promote sympathetic nervous system activation, had a functional impact on human fat cell responsiveness to catecholamines and .beta.-agonists. The lipolytic activity of isolated sc fat cells was measured before and after a period of exercise in trained and sedentary women with a similar body mass index values [20.4 .+-. 0.5 (.+-. SE) and 21.3 .+-. 0.5 kg/m2] and an equivalent mean fat cell volume (0.216 .+-. 0.022 vs. 0.278 pm 0.026 nL). Before exercise, compared with those of sedentary women, the adipocytes of trained women had greater lipolytic responsiveness to catecholamines and .beta.-agonists; moreover, dibutyryl cAMP had greater lipolytic efficiency on the adipocytes of the trained women. These results suggest that the differences in responsiveness of the adipocytes from sedentary and trained women are due to functional differences at a postreceptor level of the lipolytic cascade. The lipolytic (.beta.-adrenergic) and antilipolytic (.alpha.2-adrenergic) responses of the adipocytes from both groups did not change after the period of physical activity. These results demonstrate, whatever the physical condition of the subjects, that desensitizaiton of .beta.- and .alpha.2-adrenergic responsiveness does not occur after a period of intense physical activity which promotes physiological activation of the sympathetic nervous system.