Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment
Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment
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DOI：
10.1016/s0024-3205(00)00712-8
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发表时间：
2000-07-28
期刊：
影响因子：
6.1
通讯作者：
Giuliano, G
中科院分区：
文献类型：
--
作者：
Boscolo, P;Di Gioacchino, M;Giuliano, G
本研究评估了30名非特应性和30名无症状的呼吸道和/或皮肤过敏史的女性暴露于城市环境的免疫反应。血淋巴细胞亚群和血清白细胞介素（IL）4和干扰素γ（INF-γ）的两组是相似的，而血清IgE和“体外”生产的IL-4和INF-γ的单核血细胞的特应性妇女自发或在PHA的存在下，分别较高。正常妇女血铅水平（平均55 μ g/l）与CD 4 +-CD 45 RO-、CD 3 +-CD 8+和CD 3- -HLA-DR+淋巴细胞亚群呈正相关，而尿反式-反式粘康酸（苯的代谢物）的两组妇女（平均约50 μ g/l）与NK CD 16 +-CD 56+淋巴细胞显著相关，非特应性个体尿铬与活化的T、B和NK HLA-DRS细胞显著相关。两组妇女的尿镍与CD 4 +-CD 45 RO+“记忆”淋巴细胞及其与CD 4 +-CD 45 RO-“处女”淋巴细胞的比率相关，表明金属促进“处女”淋巴细胞成熟为“记忆”淋巴细胞。总的来说，这项研究表明，暴露于城市环境中车辆交通产生的低水平有毒物质，对妇女的免疫功能产生影响。(C)2000 Elsevier Science Inc. All rights reserved.
This study evaluates the immune response to exposure to an urban environment from 30 non-atopic and 30 non-symptomatic women with history of respiratory and/or cutaneous allergies. Blood lymphocyte subsets and serum interleukin (IL) 4 and interferon gamma (INF-gamma) of the two groups were similar, while serum IgE and "in vitro" production of IL-4 and INF-gamma by mononuclear blood cells of the atopic women were higher spontaneously or in the presence of PHA, respectively. Blood lead of the nonatopic women (mean 55 mu g/l) was positively correlated with CD4+-CD45RO-, CD3+-CD8+ and CD3- -HLA-DR+ lymphocyte subsets, while urinary trans-trans muconic acid (a metabolite of benzene) of both groups of women (mean about 50 mu g/l) was significantly correlated with NK CD16+-CD56+ lymphocytes, Urine chromium of the non-atopic subjects was significantly correlated with activated T, B and NK HLA-DRS cells. Urine nickel of both groups of women was correlated with CD4+-CD45RO+ "memory" lymphocytes and their ratio with CD4+-CD45RO- "virgin" lymphocytes suggesting that the metal enhances maturation of "virgin" into "memory" lymphocytes. On the whole, this study demonstrates that exposure to low levels of toxic agents, produced by vehicular traffic in an urban environment, exerts effects on immune functions of women. (C) 2000 Elsevier Science Inc. All rights reserved.