Neural Processing and Production of Gesture in Children and Adolescents With Autism Spectrum Disorder
Neural Processing and Production of Gesture in Children and Adolescents With Autism Spectrum Disorder
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DOI：
10.3389/fpsyg.2019.03045
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发表时间：
2020-01-22
影响因子：
3.8
通讯作者：
Rivera, Susan M.
中科院分区：
文献类型：
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作者：
Fourie, Emily;Palser, Eleanor R.;Rivera, Susan M.
自闭症谱系障碍（ASD）患者表现出非语言交流障碍，包括手势和模仿缺陷。ASD患者对生物运动（BM）的敏感性降低可能会损害对动态社交线索（如手势）的处理，这反过来可能会阻碍这些动作的编码和后续表现。使用fMRI任务，包括观察动作手势和charade风格的范式评估手势的性能，本研究探讨了大脑行为之间的关系，在手势处理过程中的神经活动，手势能力和社会行为学在一组儿童和青少年与ASD。与典型发育（TD）对照组相比，ASD患者对右后上级颞沟（pSTS）（一个涉及动作处理的区域）的运动表现出非典型的敏感性，并且整体手势表现较差，手部姿势存在特定缺陷。TD组显示神经活动，手势表现和社交技能之间的关联，在ASD组中很弱或不显着。这些研究结果表明，那些与ASD表现出异常的处理和生产的手势，并可能反映功能障碍的机制，导致非典型的社会和沟通技能的感知-行动耦合。
Individuals with autism spectrum disorder (ASD) demonstrate impairments in non-verbal communication, including gesturing and imitation deficits. Reduced sensitivity to biological motion (BM) in ASD may impair processing of dynamic social cues like gestures, which in turn may impede encoding and subsequent performance of these actions. Using both an fMRI task involving observation of action gestures and a charade style paradigm assessing gesture performance, this study examined the brain-behavior relationships between neural activity during gesture processing, gesturing abilities and social symptomology in a group of children and adolescents with and without ASD. Compared to typically developing (TD) controls, participants with ASD showed atypical sensitivity to movement in right posterior superior temporal sulcus (pSTS), a region implicated in action processing, and had poorer overall gesture performance with specific deficits in hand posture. The TD group showed associations between neural activity, gesture performance and social skills, that were weak or non-significant in the ASD group. These findings suggest that those with ASD demonstrate abnormalities in both processing and production of gestures and may reflect dysfunction in the mechanism underlying perception-action coupling resulting in atypical development of social and communicative skills.