INTEGRINS AND MODULATION OF TRANSMITTER RELEASE FROM MOTOR-NERVE TERMINALS BY STRETCH
INTEGRINS AND MODULATION OF TRANSMITTER RELEASE FROM MOTOR-NERVE TERMINALS BY STRETCH
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DOI：
10.1126/science.7667637
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发表时间：
1995-09-15
期刊：
影响因子：
56.9
通讯作者：
GRINNELL, AD
中科院分区：
文献类型：
--
作者：
CHEN, BM;GRINNELL, AD
青蛙肌肉在生理范围内的拉伸可以使其运动神经末梢自发释放和诱发释放的神经递质增加一倍以上。在这里，释放的拉伸增强被含有序列精氨酸-甘氨酸-天冬氨酸（RGD）的肽抑制，该序列阻止整合素结合。整合素抗体也抑制通过拉伸获得的增强。拉伸增强取决于来自外部钙和内部储存的末端内钙。因此，肌肉拉伸可能通过提高内部钙浓度或增加神经末梢神经递质释放对钙的敏感性来增强神经递质的释放。
The stretch of a frog muscle within the physiological range can more than double the spontaneous and evoked release of neurotransmitter from its motor nerve terminals. Here, stretch enhancement of release was suppressed by peptides containing the sequence arginine-glycine-aspartic acid (RGD), which blocks integrin binding. Integrin antibodies also inhibited the enhancement obtained by stretching. Stretch enhancement depended on intraterminal calcium derived both from external calcium and from internal stores. Muscle stretch thus might enhance the release of neurotransmitters either by elevating internal calcium concentrations or by increasing the sensitivity of transmitter release to calcium in the nerve terminal.