The Notch pathway: a crossroad between the life and death of the endothelium
The Notch pathway: a crossroad between the life and death of the endothelium
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DOI：
10.1093/eurheartj/ehs141
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发表时间：
2013-08-01
影响因子：
39.3
通讯作者：
Ferrari, Roberto
中科院分区：
文献类型：
--
作者：
Rizzo, Paola;Miele, Lucio;Ferrari, Roberto
内皮细胞越来越受到肿瘤学家和心脏病学家的关注。通过诱导内皮损伤来抑制肿瘤中的血管生成被认为是一种有前途的治疗方法。相反，内皮损伤与动脉粥样硬化、血栓形成、高血压和糖尿病有关。内皮细胞死亡通过细胞凋亡发生，成熟内皮细胞的再生能力有限：只要内皮细胞的死亡和再生之间出现不平衡，其完整性和功能就会受到威胁，并且有利于心血管疾病的起源和进展。Notch信号传导参与细胞命运决定，并且已显示直接或通过与其他途径交叉作用来调节内皮细胞的凋亡、再生、增殖和迁移。1，2抑制Notch途径在肿瘤学中可用于抑制肿瘤中的血管生成3，4，但其操作可用于心脏病学中以减少内皮细胞凋亡并促进血管生成。
The endothelium is attracting increasing attention from oncologists and cardiologists. Inhibition of angiogenesis in tumours by the induction of endothelial injury is considered a promising therapeutic approach. Conversely, endothelial injury is implicated in atherosclerosis, thrombosis, hypertension, and diabetes. Endothelial death occurs by apoptosis and the regenerative capacity of mature endothelial cells is limited: wherever an imbalance between death and regeneration of the endothelium occurs, its integrity and function is threatened and the origin and progression of cardiovascular disease is favoured. Notch signalling is involved in the cell fate decision and, directly or by cross-talking with other pathways, has been shown to regulate apoptosis, regeneration, proliferation, and migration of endothelial cells. 1, 2 Inhibition of the Notch pathways is useful in oncology to repress angiogenesis in tumours 3, 4 but its manipulation could be useful in cardiology to reduce endothelial apoptosis and to favour angiogenesis.