Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial.
Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial.
复制标题
DOI：
10.7554/elife.62278
复制
发表时间：
2021-04-09
期刊：
影响因子：
7.7
通讯作者：
Brown J
中科院分区：
文献类型：
--
作者：
Knee J;Sumner T;Adriano Z;Anderson C;Bush F;Capone D;Casmo V;Holcomb D;Kolsky P;MacDougall A;Molotkova E;Braga JM;Russo C;Schmidt WP;Stewart J;Zambrana W;Zuin V;Nalá R;Cumming O;Brown J
我们进行了一项前后对照试验，以评估现场城市卫生干预对莫桑比克马普托儿童肠道感染、土壤传播蠕虫再感染和腹泻患病率的影响。一个非政府组织用带化粪池的冲水式厕所取代了现有的劣质厕所，为家庭群体提供服务。我们招募了基线时年龄为 1-48 个月的儿童，并测量了干预前、干预后 12 个月和 24 个月的结果，同时对可比对照组的儿童进行了测量。尽管几乎是独家使用，但我们没有发现任何证据表明干预措施会影响暴露 12 或 24 个月后任何测量结果的发生率。在干预后在研究地点出生的儿童中，我们观察到相对于基线时相同年龄组（<2 岁），鞭毛虫和志贺氏菌感染的患病率有所降低。在这种情况下，出生时的保护对于减少肠道病原体的接触和感染可能很重要。
We conducted a controlled before-and-after trial to evaluate the impact of an onsite urban sanitation intervention on the prevalence of enteric infection, soil transmitted helminth re-infection, and diarrhea among children in Maputo, Mozambique. A non-governmental organization replaced existing poor-quality latrines with pour-flush toilets with septic tanks serving household clusters. We enrolled children aged 1–48 months at baseline and measured outcomes before and 12 and 24 months after the intervention, with concurrent measurement among children in a comparable control arm. Despite nearly exclusive use, we found no evidence that intervention affected the prevalence of any measured outcome after 12 or 24 months of exposure. Among children born into study sites after intervention, we observed a reduced prevalence of Trichuris and Shigella infection relative to the same age group at baseline (<2 years old). Protection from birth may be important to reduce exposure to and infection with enteric pathogens in this setting.