Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.

Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.
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DOI:
10.3390/cancers12092374
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发表时间:
2020-08-21
期刊:
影响因子:
5.2
通讯作者:
Mikami M
Mikami M
中科院分区:
医学2区
文献类型:
--
作者:
Matsuo K;Tanabe K;Hayashi M;Ikeda M;Yasaka M;Machida H;Shida M;Sato K;Yoshida H;Hirasawa T;Imanishi T;Mikami M

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综合血清糖肽谱分析(CSGSA)评估> 10,000种血清糖肽,并通过监督正交偏最小二乘判别建模识别独特的糖肽峰和模式。CSGSA检测早期上皮性卵巢癌的准确性高于癌抗原125(CA125)或人附睾蛋白4(HE4)。联合CSGSA、CA125和HE4的诊断性能得到改善。因此,CSGSA可能是检测早期上皮性卵巢癌的一种有用的筛查工具。
Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.
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