Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats
Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats
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DOI：
10.1016/j.bbr.2010.02.019
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发表时间：
2010-06-26
影响因子：
2.7
通讯作者：
Ribeiro, Angela Maria
中科院分区：
文献类型：
--
作者：
Borges Vigil, Fabio Antonio;Oliveira-Silva, Ieda de Fatima;Ribeiro, Angela Maria
The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TO deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function. (C) 2010 Elsevier B.V. All rights reserved.
