Predicting the Accumulation of Ionizable Pharmaceuticals and Personal Care Products in Aquatic and Terrestrial Organisms.
Predicting the Accumulation of Ionizable Pharmaceuticals and Personal Care Products in Aquatic and Terrestrial Organisms.
复制标题
预测水生和陆生生物中可电离药物和个人护理产品的积累。
DOI：
10.1002/etc.5451
复制
发表时间：
2024
影响因子：
4.1
通讯作者：
Carter LJ
中科院分区：
文献类型：
--
作者：
Carter LJ
化学品在水生和陆生生物体内的生物累积程度是旨在保护公众健康和环境免受污染和废物影响的化学品管理工作的一个基本考虑因素。许多化学品，包括大多数药品和个人护理产品（PPCP），在环境相关的pH梯度中可电离，这可能会影响其在水生和陆地系统中的命运。现有的数学模型描述了鱼类和植物中中性有机化学物质和弱酸弱碱的积累。然而，由于缺乏对主要或永久电离的PPCPs的机械见解，进一步的模型开发受到阻碍。需要在环境现实条件下进行有针对性的实验来解决以下问题：（1）强电离化学品在物种之间的分配和吸附行为是什么？(2)离子的膜渗透性如何影响PPCPs的生物累积？(3)盐类和与PPCP相关的络合物在多大程度上影响生物累积？(4)生物转化和其他消除过程在物种内部和物种之间有何不同？(5)生物累积性建模工作目前是否侧重于存在关键数据缺口和风险特征的化学品和物种？阐明这些问题有望解决电离PPCPs和相关污染物生物累积建模的关键不确定性来源。环境毒理学化学2024;43：502-512。© 2022作者。环境毒理学和化学由Wiley Periodicals LLC代表SETAC出版。
The extent to which chemicals bioaccumulate in aquatic and terrestrial organisms represents a fundamental consideration for chemicals management efforts intended to protect public health and the environment from pollution and waste. Many chemicals, including most pharmaceuticals and personal care products (PPCPs), are ionizable across environmentally relevant pH gradients, which can affect their fate in aquatic and terrestrial systems. Existing mathematical models describe the accumulation of neutral organic chemicals and weak acids and bases in both fish and plants. Further model development is hampered, however, by a lack of mechanistic insights for PPCPs that are predominantly or permanently ionized. Targeted experiments across environmentally realistic conditions are needed to address the following questions: (1) What are the partitioning and sorption behaviors of strongly ionizing chemicals among species? (2) How does membrane permeability of ions influence bioaccumulation of PPCPs? (3) To what extent are salts and associated complexes with PPCPs influencing bioaccumulation? (4) How do biotransformation and other elimination processes vary within and among species? (5) Are bioaccumulation modeling efforts currently focused on chemicals and species with key data gaps and risk profiles? Answering these questions promises to address key sources of uncertainty for bioaccumulation modeling of ionizable PPCPs and related contaminants.Environ Toxicol Chem2024;43:502–512. © 2022 The Authors.Environmental Toxicology and Chemistrypublished by Wiley Periodicals LLC on behalf of SETAC.