STATs and gene regulation
STATs and gene regulation
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DOI：
10.1126/science.277.5332.1630
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发表时间：
1997-09-12
期刊：
影响因子：
56.9
通讯作者：
Darnell, JE
中科院分区：
文献类型：
--
作者：
Darnell, JE
STATs(信号转导和转录激活子)是一类潜在的细胞质蛋白，当细胞遇到各种胞外多肽时，它们被激活参与基因调控。生物化学和分子遗传学研究已经定义了单个酪氨酸磷酸化位点，并且在一个二聚体伙伴分子中，一个Src同源2(SH2)磷酸酪氨酸结合域，一个DNA相互作用域，以及一些蛋白质-蛋白质相互作用域(与受体，其他转录因子，转录机制，也许还有酪氨酸磷酸酶)，小鼠遗传学实验已经定义了每一个已知哺乳动物STAT的关键作用，在果蝇和最近在盘状网壳菌中发现的STAT，意味着这一组双重功能蛋白质的古老进化起源。
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase), Mouse genetics experiments have defined crucial roles for each known mammalian STAT, The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.