The Spectrum of Olfactory Neural Tumors: A Light-Microscopic Immunohistochemical and Ultrastructural Analysis
The Spectrum of Olfactory Neural Tumors: A Light-Microscopic Immunohistochemical and Ultrastructural Analysis
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嗅觉神经肿瘤的谱：光镜免疫组织化学和超微结构分析
DOI：
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发表时间：
1986
影响因子：
5.6
通讯作者：
V. Gould
中科院分区：
文献类型：
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作者：
J. Taxy;N. Bharani;S. Mills;H. Frierson;V. Gould
将28例具有组织学特征的恶性嗅觉神经肿瘤分为两组：ⅰ组与经典神经母细胞瘤相似（20例），ⅱ组具有神经内分泌特征（8例）。采用角蛋白、神经丝蛋白、S-100和神经元特异性烯醇化酶抗体对肿瘤进行免疫组织化学分析。神经元特异性烯醇化酶在两组中均呈阳性。单个S-100阳性细胞，在肿瘤巢内或边缘，通常在超微结构上对应于肿瘤-基质界面的雪旺细胞。两组均有少量角蛋白和神经丝蛋白单独表达或同时表达。所有11个肿瘤在超微结构上均表现出含有致密核颗粒的神经元突起。结果表明：(a)电子显微镜具有可靠的诊断功能；(b)尽管在光镜下不明显，但这些肿瘤中经常出现雪旺细胞；(c)两组肿瘤中角蛋白的意外表达。角蛋白-神经丝蛋白的单一表达或共表达可能定义了这些肿瘤的一个亚群，其临床意义目前尚不清楚。
Twenty-eight malignant olfactory neural tumors representative of the histologic spectrum commonly designated as olfactory neuroblastoma were subdivided into two groups: Group I closely resembling classical neuroblastoma (20 cases), and Group II exhibiting neuroendocrine features (eight cases). Immunohistochemically, the tumors were analyzed by using antibodies to keratin, neurofilament protein, S-100, and neuron specific enolase. Neuron specific enolase was the most consistently positive in both groups. Single S-100 positive cells, within or at the edges of tumor nests, often corresponded ultrastructurally to Schwann cells at the tumor-stroma interface. Keratin and neurofilament proteins were expressed singly or together by a small number of cases in both groups. All 11 tumors examined ultrastructurally exhibited neuronal processes containing dense-core granules. The results indicate the following: (a) the reliable diagnostic utility of electron microscopy; (b) the frequent occurrence of Schwann cells in these tumors despite their inconspicuousness by light microscopy; and (c) the unexpected expression of keratin by tumors in both groups. The single or coexpression of keratin-neurofilament protein may define a subset of these tumors for which the clinical significance is presently unclear.