Insulin and glucose: relationships with hassles, anger, and hostility in nondiabetic older adults.
Insulin and glucose: relationships with hassles, anger, and hostility in nondiabetic older adults.
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胰岛素和葡萄糖：非糖尿病老年人与麻烦、愤怒和敌意的关系。
DOI：
10.1097/00006842-199609000-00011
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发表时间：
1996
影响因子：
3.3
通讯作者：
Fujimoto,W
中科院分区：
文献类型：
--
作者：
Vitaliano,PP;Scanlan,JM;Krenz,C;Fujimoto,W
研究了心理社会因素（愤怒、敌意、麻烦和照顾）与空腹胰岛素和血糖水平的关系。样本包括两组非糖尿病成人（平均年龄= 69.4岁）：诊断为阿尔茨海默病（AD）的个体的配偶照顾者（CG）（N= 78）和年龄和性别匹配的非痴呆对照（CO）的配偶（N= 72）。在15至18个月的间隔期内，对这些组进行了两次评估。为了获得更稳定的评估，所有生物心理社会指标都是一段时间内的平均值。心理社会因素与胰岛素和葡萄糖相关，即使在控制了重要的健康变量：肥胖，血脂和心血管疾病之后。正如假设的那样，具有高愤怒/敌意（AOHO）的CG具有比所有其他组组合显著更高的葡萄糖水平。高麻烦或高AOHO的受试者的葡萄糖水平显著高于这两个因素均低的受试者。对于胰岛素，AOHO、麻烦和性别激素替代疗法（HRT）之间存在三方相互作用;在接受HRT的女性中，胰岛素与AOHO和麻烦之间没有关系。在没有接受HRT的女性中，那些高AOHO和高麻烦的人的胰岛素水平显著高于其他三种组合，而在男性中，那些高AOHO或高麻烦的人的胰岛素水平显著高于这两个因素都低的男性。鉴于这些结果，未来的研究应该检查代谢过程与心理社会变量、性别和HRT之间的相互作用对非糖尿病患者的长期健康影响的程度。
Relationships of psychosocial factors (anger, hostility, hassles, and caregiving) with fasting insulin and glucose levels were examined. Samples included two groups of nondiabetic adults (mean age= 69.4 years): spouse caregivers (CG) of individuals with diagnoses of Alzheimer's disease (AD)(N= 78) and spouses of nondemented controls (CO)(N= 72) matched for age and gender. The groups were assessed twice with a 15-to 18-month hiatus. To obtain more stable assessments, all biopsychosocial measures were averaged over time. Psychosocial factors were associated with insulin and glucose, even after controlling for significant health variables: obesity, lipids, and cardiovascular disease. As hypothesized, CG with high anger-out/hostility (AOHO) had significantly higher glucose levels than all other group combinations. The glucose levels for subjects with high hassles or high AOHO were significantly higher than those for subjects who were low on both of these factors. For insulin, a three-way interaction occurred among AOHO, hassles, and genderhormone replacement therapy (HRT); in women taking HRT, no relationships occurred between insulin with AOHO and hassles. In women not taking HRT, those with high AOHO and high hassles had significantly higher insulin levels than the other three combinations, whereas in men, those with either high AOHO or high hassles had significantly higher insulin levels than men who were low on both of these factors. Given these results, future research should examine the degree to which interactions between metabolic processes with psychosocial variables, gender, and HRT have long term health consequences in nondiabetics.