The HUNT study: participation is associated with survival and depends on socioeconomic status, diseases and symptoms
The HUNT study: participation is associated with survival and depends on socioeconomic status, diseases and symptoms
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DOI：
10.1186/1471-2288-12-143
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发表时间：
2012-09-14
影响因子：
4
通讯作者：
Holmen, Jostein
中科院分区：
文献类型：
--
作者：
Langhammer, Arnulf;Krokstad, Steinar;Holmen, Jostein
背景：基于人群的研究对患病率、发病率和相关性研究很重要，但其外部有效性可能因参与率下降而受到威胁。在HUNT研究（HUNT3, 2006-08）的第三次调查中，50807名参与者占被邀请者的54%，因此需要进行一项非参与性研究。方法：对来自HUNT3的问卷数据进行比较，这些数据来自几个来源：对非参与者的简短问卷，从随机选择的一般做法中提取的关于特定诊断和处方药物的匿名数据，挪威统计局关于社会经济因素和死亡率的注册数据，以及挪威处方数据库关于药物消费的数据。结果：HUNT3的参与率取决于年龄、性别和症状和疾病类型，但当包括6922名非参与者的数据时，总体患病率估计值只有很小的变化。在非参与者中，与参与者报告的数据相比，非参与者数据和从一般实践中提取的数据中心血管疾病、糖尿病和精神疾病的患病率均较高，而至少在80岁以下的人群中，尿失禁、肌肉骨骼疼痛和头痛的患病率则相反。登记数据显示，非参与者的社会经济地位较低，死亡率高于参与者。结论：非参与者的社会经济地位较低，死亡率较高，几种慢性疾病的患病率较高，而在肌肉骨骼疼痛、尿失禁和头痛等常见问题上则发现相反的模式。对协会的影响应分析每一个诊断，和数据使这样的分析可能在本文中提供。
Background: Population based studies are important for prevalence, incidence and association studies, but their external validity might be threatened by decreasing participation rates. The 50 807 participants in the third survey of the HUNT Study (HUNT3, 2006-08), represented 54% of the invited, necessitating a nonparticipation study.Methods: Questionnaire data from HUNT3 were compared with data collected from several sources: a short questionnaire to nonparticipants, anonymous data on specific diagnoses and prescribed medication extracted from randomly selected general practices, registry data from Statistics Norway on socioeconomic factors and mortality, and from the Norwegian Prescription Database on drug consumption.Results: Participation rates for HUNT3 depended on age, sex and type of symptoms and diseases, but only small changes were found in the overall prevalence estimates when including data from 6922 nonparticipants. Among nonparticipants, the prevalences of cardiovascular diseases, diabetes mellitus and psychiatric disorders were higher both in nonparticipant data and data extracted from general practice, compared to that reported by participants, whilst the opposite pattern was found, at least among persons younger than 80 years, for urine incontinence, musculoskeletal pain and headache. Registry data showed that the nonparticipants had lower socioeconomic status and a higher mortality than participants.Conclusion: Nonparticipants had lower socioeconomic status, higher mortality and showed higher prevalences of several chronic diseases, whilst opposite patterns were found for common problems like musculoskeletal pain, urine incontinence and headache. The impact on associations should be analyzed for each diagnosis, and data making such analyses possible are provided in the present paper.