Prognostic significance of MYCN oncogene expression in childhood neuroblastoma
Prognostic significance of MYCN oncogene expression in childhood neuroblastoma
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DOI：
10.1200/jco.1998.16.10.3286
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发表时间：
1998-10-01
影响因子：
45.3
通讯作者：
Haber, M
中科院分区：
文献类型：
--
作者：
Bordow, SB;Norris, MD;Haber, M
目的：评估MYCN基因表达作为不同年龄神经母细胞瘤患者预后因素的意义，并确定其是否可以独立于MYCN基因扩增预测预后。患者和方法：采用逆转录聚合酶链反应（RT-PCR）分析60例原发性未经治疗的神经母细胞瘤标本中MYCN基因表达水平。MYCN基因的高表达水平与肿瘤的晚期阶段相关（P = 0.0005），MYCN基因扩增的存在（P
Purpose: To assess the significance of MYCN gene expression as a prognostic factor in patients with neuroblastoma of various ages, and to determine whether it can predict for outcome independently of MYCN gene amplification.Patients and Methods: The level of MYCN gene expression in 60 specimens of primary untreated neuroblastoma was determined by reverse-transcriptase polymerase chain reaction (RT-PCR) analysis,Results: High levels of MYCN gene expression were associated with advanced tumor stage (P =.0005), with the presence of MYCN gene amplification (P