Diabetic cardiomyopathy: Recent evidence from mouse models of type 1 and type 2 diabetes
Diabetic cardiomyopathy: Recent evidence from mouse models of type 1 and type 2 diabetes
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DOI：
10.1139/y04-065
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发表时间：
2004-10-01
影响因子：
2.1
通讯作者：
Severson, DL
中科院分区：
文献类型：
--
作者：
Severson, DL
糖尿病性心肌病的定义是在没有冠状动脉疾病的情况下，糖尿病心脏的心室功能障碍。通过使用体内和体外技术来评估心脏表型，可以在I型（胰岛素缺乏）和2型（胰岛素抵抗）糖尿病小鼠模型的实验中观察到收缩性能降低。在糖尿病心脏中观察到收缩功能障碍（左心室压力降低和心输出量减少）和舒张功能障碍（舒张功能受损）。同时增加了对缺血性损伤的易感性。糖尿病小鼠心脏的代谢也发生了改变：葡萄糖的利用减少，而酸的利用增加。基因工程小鼠的使用提供了一种强有力的实验方法来测试可能导致糖尿病对心功能有害影响的机制。
Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type I (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts. along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fairy acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.