Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array.
Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array.
复制标题
肌球蛋白收缩，聚集和跑步肌动蛋白阵列中的行进波。
DOI：
10.1016/j.physd.2015.10.005
复制
发表时间：
2016-04-01
期刊：
影响因子：
--
通讯作者：
Mogilner A
中科院分区：
文献类型：
--
作者：
Oelz D;Mogilner A
我们使用微扰理论推导出一个连续模型的动态肌动球蛋白束/环的制度非常强的交联。肌动蛋白研磨是收缩所必需的。线性稳定性分析和模型方程的数值解表明，当肌动蛋白的研磨速度很慢时，肌动蛋白和肌球蛋白聚集成等距分布的峰。当双相铣削显著时，一种极性的肌动蛋白丝均匀分布，而相反极性的肌动蛋白丝则产生随双相铣削速度移动的冲击波。肌球蛋白聚集成一个尖锐的峰，在肌动蛋白波的波峰冲浪。任何肌动球蛋白的聚集都会减少收缩应力。维持较高收缩的最简单方法是上调肌动球蛋白周转率，从而使非平凡模式不稳定并稳定均匀的肌动球蛋白分布。我们讨论了该模型的实验的影响。
We use perturbation theory to derive a continuum model for the dynamic actomyosin bundle/ring in the regime of very strong crosslinking. Actin treadmilling is essential for contraction. Linear stability analysis and numerical solutions of the model equations reveal that when the actin treadmilling is very slow, actin and myosin aggregate into equidistantly spaced peaks. When treadmilling is significant, actin filament of one polarity are distributed evenly, while filaments of the opposite polarity develop a shock wave moving with the treadmilling velocity. Myosin aggregates into a sharp peak surfing the crest of the actin wave. Any actomyosin aggregation diminishes contractile stress. The easiest way to maintain higher contraction is to upregulate the actomyosin turnover which destabilizes nontrivial patterns and stabilizes the homogeneous actomyosin distributions. We discuss the model’s implications for the experiment.