The point prevalence of clinically relevant primary Sjogren's syndrome in two Norwegian counties
The point prevalence of clinically relevant primary Sjogren's syndrome in two Norwegian counties
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DOI：
10.3109/03009742.2010.536164
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发表时间：
2011-01-01
影响因子：
2.1
通讯作者：
Omdal, R.
中科院分区：
文献类型：
--
作者：
Goransson, L. G.;Haldorsen, K.;Omdal, R.
目的：原发性干燥综合征（PSS）是一种以外分泌腺炎症为特征的慢性自身免疫性炎症性疾病，临床表现为口眼干燥等。报告的PSS患病率是可变的，可能是因为使用的不同分类标准和选择偏倚。本研究的目的是确定PSS的患病率在一个定义明确的挪威高加索人群使用修订后的美国-欧洲共识小组（AECG）criteria.Methods：三家医院和三个私人风湿病的做法提供所有的风湿病服务，当地人口在霍达兰和罗加兰县，其中包括852 342高加索居民作为2009年1月1日。符合PSS新修订的AECG标准的患者被纳入，数据不完整的患者被邀请到筛选vision.Results：共确定了424例PSS患者。他们的平均年龄为61.6 ± 13.2岁; 28例（7%）为男性，396例（93%）为女性。PSS比例的点估计值为0.050% [95%置信区间（CI）0.048-0.052]。结论：当使用不太严格的标准识别PSS时，挪威白人人群中PSS的患病率低于以前的报告，但与本研究中使用相同标准和方法的最新研究一致。
Objective: Primary Sjogren's syndrome (PSS) is a chronic autoimmune inflammatory disease characterized by exocrine gland inflammation producing clinical symptoms such as dryness of the mouth and eyes. The reported prevalence of PSS is variable, probably because of different classification criteria used and selection bias. The aim of this study was to determine the prevalence of PSS in a well-defined Norwegian Caucasian population using the revised American-European Consensus Group (AECG) criteria.Methods: Three hospitals and three private rheumatology practices provide all of the rheumatology services to the local population in Hordaland and Rogaland counties, which included 852 342 Caucasian inhabitants as of 1 January 2009. Patients on file fulfilling the new revised AECG criteria for PSS were included, and patients with incomplete data were invited to a screening visit.Results: A total of 424 PSS patients were identified. Their mean age was 61.6 +/- 13.2 years; 28 (7%) were men and 396 (93%) were women. The point estimate for the proportion of PSS was 0.050% [95% confidence interval (CI) 0.048-0.052].Conclusion: The prevalence of PSS in this Norwegian population of Caucasians is lower than previously reported when less stringent criteria for identifying PSS were used, but is in line with more recent studies using the same criteria and methods as in this study.