3D axonal network coupled to Microelectrode Arrays: A simulation model to study neuronal dynamics
3D axonal network coupled to Microelectrode Arrays: A simulation model to study neuronal dynamics
复制标题
DOI：
10.1109/embc.2015.7319443
复制
发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
R. Appali;K. Sriperumbudur;U. Rienen
中科院分区：
文献类型：
--
作者：
R. Appali;K. Sriperumbudur;U. Rienen
神经元中的动作电位是通过膜上的离子交换而产生和传播的。Hodgkin和Huxley(HH)模型描述了这些依赖于时间的络合离子动力学。我们在具有轴突分支的锥体神经元上实现了Fitzhugh-Nagumo模型，这是HH模型的简化版本之一，用于研究神经元的自发活动。然后将该网络耦合到微电极阵列，以记录神经芯片环境中的细胞外电位。该模型被用来研究AP与电极的耦合。这样的模型也是研究神经元形态对其信号特性影响的第一步。
Action Potentials in a neuron are generated and propagated by exchange of ions through the membrane. The model of Hodgkin and Huxley (HH) describes these time-dependent complex ion dynamics. We have implemented the FitzHugh-Nagumo model, one of the simplified versions of HH model on a pyramidal neuron with branches of axons to study the spontaneous activity of neurons. The network is then coupled to Micro-Electrode Arrays to record the extracellular potential in a neurochip environment. This in silico model is used to study the coupling of AP with the electrodes. Such a model is also a first step to investigate the morphological influence of neurons on their signaling properties.