AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.
AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.
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DOI：
10.1186/1756-6614-4-s1-s5
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发表时间：
2011-08-03
期刊：
影响因子：
2.2
通讯作者：
Hoang-Vu C
中科院分区：
文献类型：
--
作者：
Trojanowicz B;Dralle H;Hoang-Vu C
RNA结合蛋白可以调控RNA代谢的各个方面，包括pre-mRNA剪接、mRNA转运、许多基因的稳定性和翻译。这些蛋白质与RNA的动态关联决定了特定mRNA的寿命、细胞定位、加工和翻译速度。调控mRNA稳定性的途径之一是由富含腺苷酸尿苷酸元素（ARE）结合蛋白介导的。这些蛋白参与细胞凋亡、肿瘤发生和发展的过程。在许多are结合蛋白中，研究最广泛的是AUF1和HuR两种，据报道它们在体内调节mRNA的稳定性。我们之前发表的数据表明，这两种蛋白都参与甲状腺癌的发生。其他一些报道假设mRNA结合蛋白可能参与甲状腺激素的作用。然而，到目前为止，确切的机制和转录后调控的可能作用，特别是AUF1和HuR在这些过程中的作用仍未完全了解。在这项研究中，我们简要回顾了这两种蛋白在发育和各种生理和病理生理过程中的可能功能，包括甲状腺功能和疾病。
RNA-binding proteins may regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability and translation of many genes. The dynamic association of these proteins with RNA defines the lifetime, cellular localization, processing and the rate at which a specific mRNA is translated. One of the pathways involved in regulating of mRNA stability is mediated by adenylate uridylate-rich element (ARE) binding proteins. These proteins are involved in processes of apoptosis, tumorigenesis and development. Out of many ARE-binding proteins, two of them AUF1 and HuR were studied most extensively and reported to regulate the mRNA stability in vivo. Our previously published data demonstrate that both proteins are involved in thyroid carcinogenesis. Several other reports postulate that mRNA binding proteins may participate in thyroid hormone actions. However, until now, exacts mechanisms and the possible role of post-transcriptional regulation and especially the role of AUF1 and HuR in those processes remain not fully understood. In this study we shortly review the possible function of both proteins in relation to development and various physiological and pathophysiological processes, including thyroid function and disorders.