Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma.
Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma.
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DOI：
10.1038/sj.bjc.6604715
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发表时间：
2008-11-04
影响因子：
8.8
通讯作者：
Fujii H
中科院分区：
文献类型：
--
作者：
Mizukami Y;Kono K;Maruyama T;Watanabe M;Kawaguchi Y;Kamimura K;Fujii H
由于在人白细胞抗原（HLA）I类分子的背景下的抗原肽被细胞毒性T淋巴细胞（CTL）识别，HLA I类分子的下调是肿瘤细胞可以逃避CTL介导的抗肿瘤免疫的原因之一。在这项研究中，我们调查了食管鳞状细胞癌（ESCC）（n=70）及其转移灶（淋巴结（n=40）和肝脏（n=3））的HLA I类表达，免疫组化与抗HLA I类单克隆抗体（EMR 8 -5）。结果，43%的ESCC原发灶中HLA I类表达下调，90%的转移淋巴结中HLA I类表达下调。此外，原发肿瘤中HLA I类分子表达保留的患者与HLA I类分子表达下调的患者相比，生存率更高（P<0.01）。考克斯比例风险模型多因素分析显示，原发灶HLA I类表达下调是独立的预后不良因素（P<0.01）。总之，HLA-I类表达的下调经常发生在原发性肿瘤，并在更大程度上，在转移性病变的食管鳞癌患者，并与患者的生存率。
As antigenic peptides in the context of human leukocyte antigen (HLA) class I molecules are recognised by cytotoxic T lymphocytes (CTL), the downregulation of HLA class I molecules is one of the reasons why tumour cells can evade CTL-mediated anti-tumour immunity. In this study, we investigated HLA class I expression in oesophageal squamous cell carcinoma (ESCC) (n=70) and in their metastatic lesions (lymph nodes (n=40) and liver (n=3)), by immunohistochemistry with anti-HLA class I monoclonal antibody (EMR8-5). As a result, the downregulation of HLA class I expression in primary lesions of ESCC was observed in 43%, and that in metastatic lymph nodes was noted in 90%. Furthermore, patients with preserved HLA class I expression in primary tumours showed a better survival in comparison to those with downregulated HLA class I molecules (P<0.01). Furthermore, multivariate analysis using Cox's proportional hazards model revealed that the downregulated expression of HLA class I in primary lesions was an independent, unfavourable prognostic factor (P<0.01). In conclusion, the downregulation of HLA class I expression frequently occurred in primary tumour and, to a greater extent, in metastatic lesions of patients with ESCC and was associated with patient survival.
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抗原加工机械和HLA I类缺陷与宫颈癌中临床病理结果的关联。
影响因子：
5.8
作者：
Mehta, Akash M.;Jordanova, Ekaterina S.;Kenter, Gemma G.;Ferrone, Soldano;Fleuren, Gert-Jan
通讯作者：
Fleuren, Gert-Jan
DOI：
10.1084/jem.194.6.833
发表时间：
2001-09-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Tangri S;Ishioka GY;Huang X;Sidney J;Southwood S;Fikes J;Sette A
通讯作者：
Sette A
影响因子：
5.8
作者：
Ramnath, N;Tan, D;Ferrone, S
通讯作者：
Ferrone, S
影响因子：
5.8
作者：
Seliger, Barbara
通讯作者：
Seliger, Barbara
影响因子：
4.7
作者：
Nie, Y;Yang, GY;Yang, CS
通讯作者：
Yang, CS