Fetal lung volume: Estimation at MR imaging - Initial results
Fetal lung volume: Estimation at MR imaging - Initial results
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DOI：
10.1148/radiology.219.1.r01ap18236
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发表时间：
2001-04-01
期刊：
影响因子：
19.7
通讯作者：
Eurin, D
中科院分区：
文献类型：
--
作者：
Rypens, F;Metens, T;Eurin, D
目的：绘制由快速自旋回波磁共振(MR)成像获得的正常胎儿肺体积(FLV)与胎龄的关系；探讨肺生长与胎儿头位、性别和超声(US)生物测量的相关性；并探讨其在胸腹畸形胎儿中的潜在应用。材料与方法：在一项前瞻性多中心研究中，对336例疑似患有中枢神经系统疾病的胎儿进行了快速自旋回波T2加权肺成像。选择215例无胸腹畸形且US生物测量结果正常的胎儿在妊娠21-38周时获得的数据作为FLV标准曲线。对11例胎儿用浸润法进行病理检查，并与MR测量的FLV进行比较。结果：正常胎儿FLV随胎龄增加呈幂曲线增长，数值分布随胎龄增加而增大。观察者间相关性良好(R2=0.96)。MRI测量的FLV是病理检查的0.90倍。左右两侧的血流速度之比为0.78。不同胎位胎儿的FLV差异无统计学意义。所有囊性腺瘤样畸形的胎儿和羊水过少的6例胎儿中有4例观察到正常的FLV。结论：在肺功能正常的胎儿中，快速自旋回波T2加权成像可以很容易地评估胎儿子宫内的FLV分布与胎龄的关系。这些初步发现说明了将肺发育不良风险胎儿的FLV测量值与正常值进行比较的可能性。
PURPOSE: To plot normal fetal lung volume (FLV) obtained with fast spin-echo magnetic resonance (MR) images against gestational age; to investigate the correlation between lung growth and fetal presentation, sex, and ultrasonographic (US) biometric measurements; and to investigate its potential application in fetuses with thoracoabdominal malformations.MATERIALS AND METHODS: In a prospective multicenter study, 336 fetuses suspected of having central nervous system disorders underwent fast spin-echo T2-weighted lung MR imaging. Data obtained at 21-38 weeks gestation in 215 fetuses without thoracoabdominal malformations and with normal US biometric findings were selected for an FLV normative curve. FLV measurements obtained at pathologic examination with an immersion method were compared with MR FLV measurements in 11 fetuses. MR FLV values in 16 fetuses with thoracoabdominal malformations were compared with the normative curve.RESULTS: Normal FLV increased with gestational age as a power curve; the spread of values increased with age. Interobserver correlation was excellent (R-2 = 0.96). FLV measurements at MR imaging were 0.90 times those at pathologic examination. A constant ratio (0.78) between FLV on the left and right sides was observed. No significant difference in FLV was observed between fetal presentations. Normal FLV was observed in all fetuses with cystic adenomatoid malformations and in four of six with oligohydramnios. Lowest FLV values were observed in fetuses with diaphragmatic hernia.CONCLUSION: In fetuses with normal lungs, FLV distribution against gestational age is easily assessed in utero with fast spin-echo T2-weighted MR imaging. These preliminary findings illustrate the potential for comparing FLV measurements in fetuses at risk of lung hypoplasia with normative values.