Cell encapsulation: Promise and progress
Cell encapsulation: Promise and progress
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DOI：
10.1038/nm0103-104
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发表时间：
2003-01-01
期刊：
影响因子：
82.9
通讯作者：
Luis Pedraz, Jose
中科院分区：
文献类型：
--
作者：
Orive, Gorka;Maria Hernandez, Rosa;Luis Pedraz, Jose
在细胞封装中，移植的细胞通过人工半透膜保护免受免疫排斥，潜在地允许移植(同种或异种移植)而不需要免疫抑制。然而，尽管在动物研究中取得了一些有希望的结果，但该领域并没有达到预期，基于微囊化细胞技术的临床产品继续躲避科学界。这篇评论讨论了原因，总结了该领域的最新进展，并概述了需要什么才能使这项技术更接近临床应用。
In cell encapsulation, transplanted cells are protected from immune rejection by an artificial, semipermeable membrane, potentially allowing transplantation (allo-or xenotransplantation) without the need for immunosuppression. Yet, despite some promising results in animal studies, the field has not lived up to expectations, and clinical products based on encapsulated cell technology continue to elude the scientific community. This commentary discusses the reasons for this, summarizes recent progress in the field and outlines what is needed to bring this technology closer to clinical application.