Malignant lympho-epithelial lesion of the salivary gland: a case report and review of the literature.
Malignant lympho-epithelial lesion of the salivary gland: a case report and review of the literature.
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唾液腺恶性淋巴上皮病变：病例报告及文献综述。
DOI：
10.1111/j.1440-1673.1993.tb00079.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
H. Llewellyn
中科院分区：
文献类型：
--
作者：
M. Borg;C. Benjamin;R. Morton;H. Llewellyn
唾液腺恶性淋巴上皮病变是一种未分化鳞状细胞癌，与显着的富含淋巴细胞的基质相关。本研究回顾了有关这种罕见肿瘤的当前文献，并参考了新西兰奥克兰出现的单一记录的唾液腺恶性淋巴上皮病变病例。这名 26 岁的白人男性的右腮腺和多个同侧颈部淋巴结出现快速生长的病变。治疗包括手术和放射治疗。患者目前无病。文献中还报道了 108 例其他病例，其中 82 例有蒙古血统（爱斯基摩人和中国南方人），15 例是白种人。超过 50% 的这些患者（均为蒙古人）的血清免疫球蛋白 A 抗 Epstein-Barr 病毒衣壳抗原的滴度升高。就诊年龄各不相同，从 10 岁到 86 岁不等，其中女性略多。 41% 的患者出现区域淋巴结转移，20% 出现远处转移。鉴于这种疾病的罕见性，治疗方法存在争议。目前的数据表明，采用手术和放疗的早期根治性联合治疗可延长生存期和治愈率，5 年生存率大于 50%。
Malignant lympho-epithelial lesion of the salivary gland is an undifferentiated squamous cell carcinoma which is associated with a prominent lymphocyte-rich stroma. This study reviews the current literature pertaining to this rare tumour with reference to the single recorded case of malignant lympho-epithelial lesion of the salivary gland presenting in Auckland, New Zealand. This 26 year old Caucasian male developed a rapidly growing lesion in the right parotid gland and multiple ipsilateral cervical lymph nodes. Treatment consisted of surgery and radiotherapy. The patients is currently disease free. One hundred and eight other cases have been reported in the literature, 82 of whom have Mongolian ancestry (Eskimos and southern Chinese) and 15 of whom are Caucasian. More than 50% of these patients (all Mongolian) have elevated titres of serum immunoglobulin A against Epstein-Barr virus capsid antigen. The age at presentation is variable, ranging from 10 to 86 years, with a slight female predominance. Forty-one per cent of patients present with regional lymph node metastases and 20% with distant metastases. Given the rarity of this disease, treatment is controversial. Current data suggest that early radical combined modality treatment using surgery and radiotherapy leads to prolonged survival and cure with 5 year survival rates greater than 50%.