Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases
Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases
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DOI：
10.1016/s0009-2797(97)00117-8
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发表时间：
1998-02-20
影响因子：
5.1
通讯作者：
Innes, NP
中科院分区：
文献类型：
--
作者：
Coughtrie, MWH;Sharp, S;Innes, NP
硫酸化和硫酸盐缀合水解在代谢中起重要作用，并由硫转移酶和硫酸酯酶超家族成员催化。一般来说，硫酸化是一种失活、解毒的途径，但对于某些化学物质，硫酸盐缀合物比母体化合物反应性强得多。硫酸化的化合物种类繁多，但我们对这一途径的功能仍然知之甚少。本文综述了目前关于硫酸化系统和相关酶的知识，并说明了硫转移酶（SULTs）和磺化酶的异源表达如何帮助我们了解这些重要蛋白质的性质。本文讨论了硫酸化在致癌物原和促生剂生物活性中的作用，并介绍了茶和咖啡等常见膳食成分对硫转移酶的抑制作用。遗传和环境因素，这是已知的影响人类SULTs和硫酸盐酶的活性和表达也进行了审查。(C) 1998爱思唯尔科学爱尔兰有限公司版权所有。
Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent compound. The range of compounds which are sulfated is enormous, yet we still understand relatively little of the function of this pathway. This review summarises current knowledge of the sulfation system and the enzymes involved, and illustrates how heterologous expression of sulfotransferases (SULTs) and sulfatases is aiding our appreciation of the properties of these important proteins. The role of sulfation in the bioactivation of procarcinogens and promutagens is discussed, and new data on the inhibition of the sulfotransferase(s) involved by common dietary components such as tea and coffee are presented. The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.