Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort.
Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort.
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DOI：
10.1093/aje/kwn358
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发表时间：
2008-12
影响因子：
5
通讯作者：
Jie-Jin Wang;E. Rochtchina;Wayne T Smith;R. Klein;B. Klein;T. Joshi;T. A. Sivakumaran;S. Iyengar;P. Mitchell
中科院分区：
文献类型：
--
作者：
Jie-Jin Wang;E. Rochtchina;Wayne T Smith;R. Klein;B. Klein;T. Joshi;T. A. Sivakumaran;S. Iyengar;P. Mitchell
在1992-1994年的基线，作者评估了3,654名年龄≥ 49岁的人中补体因子H（CFH）基因型与吸烟、鱼类消费和炎症标志物对年龄相关性黄斑变性（AMD）风险的综合影响。他们在5年和10年后重新检查了75%的幸存者，通过并排摄影分级确认了AMD事件。在蓝山眼科研究的2,452人中，1,881人进行了基因分型（rs 1061170），CC，CT和TT分别为13.6%，46.7%和39.7%。AMD风险随着每个额外的C等位基因而增加（早期AMD：年龄和性别调整的相对风险（RR）= 1.6，95%置信区间（CI）：1.2，1.9;晚期AMD：RR = 2.3，95% CI：1.5，3.6）。目前吸烟的CC/CT基因型（RR = 10.7，95% CI：3.4，33.9）的晚期AMD风险是基因型相似的非吸烟者（RR = 2.2，95% CI：0.9，5.5）与目前不吸烟的TT基因型的5倍。与少于每周食用鱼相比，每周食用鱼与CC基因型（RR = 0.15，95% CI：0.03，0.8）参与者的晚期AMD风险降低相关，但与CT（RR = 0.7，95% CI：0.3，2.0）或TT（RR = 1.3，95% CI：0.2，7.2）基因型无关。这项研究记录了遗传和系统因素在决定AMD进展中的共同作用。
At baseline in 1992-1994, the authors assessed the combined effects of complement factor H (CFH) genotypes with smoking, fish consumption, and inflammatory markers on the risk of age-related macular degeneration (AMD) in 3,654 persons aged > or =49 years. They reexamined 75% of the survivors after 5 and 10 years, confirming incident AMD by side-by-side photographic grading. Of the 2,452 persons followed in the Blue Mountains Eye Study, 1,881 were genotyped (rs1061170), with CC, CT, and TT identified in 13.6%, 46.7%, and 39.7%, respectively. AMD risk increased with each additional C allele (early AMD: age- and sex-adjusted relative risk (RR) = 1.6, 95% confidence interval (CI): 1.2, 1.9; late AMD: RR = 2.3, 95% CI: 1.5, 3.6). Late AMD risk among current smokers with the CC/CT genotypes (RR = 10.7, 95% CI: 3.4, 33.9) was 5-fold that for genotypically similar nonsmokers (RR = 2.2, 95% CI: 0.9, 5.5) versus current nonsmokers with TT genotypes. Weekly compared with less than weekly consumption of fish was associated with reduced late AMD risk in participants with the CC genotype (RR = 0.15, 95% CI: 0.03, 0.8) but not the CT (RR = 0.7, 95% CI: 0.3, 2.0) or TT (RR = 1.3, 95% CI: 0.2, 7.2) genotypes. This study documents joint contributions from genetic and systemic factors in determining the progression of AMD.