Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
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DOI：
10.1016/j.eurpsy.2015.08.009
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Gabbay V
中科院分区：
文献类型：
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作者：
Bradley KA;Mao X;Case JA;Kang G;Shungu DC;Gabbay V
线粒体功能障碍已越来越多地被视为精神疾病的潜在致病事件，尽管其在重度抑郁症（MDD）早期病程中的作用尚不清楚。因此，本研究的目的是通过使用高空间分辨率多层/多体素质子磁共振波谱在体内测量神经代谢物，研究无药物治疗的MDD青少年的线粒体功能障碍。23例MDD青少年和29例健康对照者，年龄12-20岁，在3 T下进行扫描，并报告了双侧尾状核、壳核和丘脑中的脑室脑脊液乳酸盐、N-乙酰天冬氨酸（NAA）、总肌酸（tCr）和总胆碱（tCho）浓度。与健康对照组相比，MDD青少年的心室乳酸增加[F（1，41）= 6.98，p = .01]。然而，其他神经代谢物无组间差异。抑郁组的维度分析显示，任何神经代谢物与神经病学（包括快感缺乏和疲劳）之间均无相关性。抑郁症青少年心室乳酸增加表明线粒体功能障碍可能存在于MDD的早期过程中;然而，目前尚不清楚线粒体功能障碍的存在是否是易患精神病理学的个体的一种特质脆弱性或该疾病的一种状态特征。因此，有必要进行更大规模的多模态研究，以澄清这些化学发现的网络功能的背景下。
Mitochondrial dysfunction has been increasingly examined as a potential pathogenic event in psychiatric disorders, although its role early in the course of major depressive disorder (MDD) is unclear. Therefore, the purpose of this study was to investigate mitochondrial dysfunction in medication-free adolescents with MDD through in vivo measurements of neurometabolites using high-spatial resolution multislice/multivoxel proton magnetic resonance spectroscopy. Twenty-three adolescents with MDD and 29 healthy controls, ages 12–20, were scanned at 3T and concentrations of ventricular cerebrospinal fluid lactate, as well as N-acetyl-aspartate (NAA), total creatine (tCr), and total choline (tCho) in the bilateral caudate, putamen, and thalamus were reported. Adolescents with MDD exhibited increased ventricular lactate compared to healthy controls [F(1, 41) = 6.98, p = .01]. However, there were no group differences in the other neurometabolites. Dimensional analyses in the depressed group showed no relation between any of the neurometabolites and symptomatology, including anhedonia and fatigue. Increased ventricular lactate in depressed adolescents suggests mitochondrial dysfunction may be present early in the course of MDD; however it is still not known whether the presence of mitochondrial dysfunction is a trait vulnerability of individuals predisposed to psychopathology or a state feature of the disorder. Therefore, there is a need for larger multimodal studies to clarify these chemical findings in the context of network function.